Oximetry of tissue vasculature with near infrared spectroscopy

Application to tumors

Hanli Liu, Yueqing Gu, Jae G. Kim, Ralph P. Mason

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Near Infrared (NIR) spectroscopy has been demonstrated as a new means to quantify oxygenation of tissue vasculature, in particular changes in hemoglobin concentrations and oxygen saturation. A novel application such oximetry to monitoring of tumor vascular oxygenation during respiratory interventions will be presented. Our recent results obtained with a one-channel NIR spectrometer observing rat breast and prostate tumors in vivo have demonstrated a biphasic response of tumor vascular oxygenation when the inhaled gas is switched from air to carbogen. We present a mathematical model associating the tumor vascular oxygenation to both well-perfused and poorly perfused regions in the tumor. Furthermore, laboratory phantom experiments and computational simulations using the Finite Element Method have been conducted to verify this tumor hemodynamic model.

Original languageEnglish (US)
Title of host publicationOSA Trends in Optics and Photonics Series
PublisherOptical Society of American (OSA)
Pages198-201
Number of pages4
Volume88
StatePublished - 2003
EventConference on Lasers and Electro-Optics (CLEO); Postconference Digest - Baltimore, MD, United States
Duration: Jun 1 2003Jun 6 2003

Other

OtherConference on Lasers and Electro-Optics (CLEO); Postconference Digest
CountryUnited States
CityBaltimore, MD
Period6/1/036/6/03

Fingerprint

Near infrared spectroscopy
Tumors
Oxygenation
Tissue
Infrared spectrometers
Hemoglobin
Hemodynamics
Rats
Mathematical models
Finite element method
Oxygen
Monitoring
Air
Gases
Experiments

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Liu, H., Gu, Y., Kim, J. G., & Mason, R. P. (2003). Oximetry of tissue vasculature with near infrared spectroscopy: Application to tumors. In OSA Trends in Optics and Photonics Series (Vol. 88, pp. 198-201). Optical Society of American (OSA).

Oximetry of tissue vasculature with near infrared spectroscopy : Application to tumors. / Liu, Hanli; Gu, Yueqing; Kim, Jae G.; Mason, Ralph P.

OSA Trends in Optics and Photonics Series. Vol. 88 Optical Society of American (OSA), 2003. p. 198-201.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liu, H, Gu, Y, Kim, JG & Mason, RP 2003, Oximetry of tissue vasculature with near infrared spectroscopy: Application to tumors. in OSA Trends in Optics and Photonics Series. vol. 88, Optical Society of American (OSA), pp. 198-201, Conference on Lasers and Electro-Optics (CLEO); Postconference Digest, Baltimore, MD, United States, 6/1/03.
Liu H, Gu Y, Kim JG, Mason RP. Oximetry of tissue vasculature with near infrared spectroscopy: Application to tumors. In OSA Trends in Optics and Photonics Series. Vol. 88. Optical Society of American (OSA). 2003. p. 198-201
Liu, Hanli ; Gu, Yueqing ; Kim, Jae G. ; Mason, Ralph P. / Oximetry of tissue vasculature with near infrared spectroscopy : Application to tumors. OSA Trends in Optics and Photonics Series. Vol. 88 Optical Society of American (OSA), 2003. pp. 198-201
@inproceedings{ea52dbfcf989493897d65dc611546ae2,
title = "Oximetry of tissue vasculature with near infrared spectroscopy: Application to tumors",
abstract = "Near Infrared (NIR) spectroscopy has been demonstrated as a new means to quantify oxygenation of tissue vasculature, in particular changes in hemoglobin concentrations and oxygen saturation. A novel application such oximetry to monitoring of tumor vascular oxygenation during respiratory interventions will be presented. Our recent results obtained with a one-channel NIR spectrometer observing rat breast and prostate tumors in vivo have demonstrated a biphasic response of tumor vascular oxygenation when the inhaled gas is switched from air to carbogen. We present a mathematical model associating the tumor vascular oxygenation to both well-perfused and poorly perfused regions in the tumor. Furthermore, laboratory phantom experiments and computational simulations using the Finite Element Method have been conducted to verify this tumor hemodynamic model.",
author = "Hanli Liu and Yueqing Gu and Kim, {Jae G.} and Mason, {Ralph P.}",
year = "2003",
language = "English (US)",
volume = "88",
pages = "198--201",
booktitle = "OSA Trends in Optics and Photonics Series",
publisher = "Optical Society of American (OSA)",

}

TY - GEN

T1 - Oximetry of tissue vasculature with near infrared spectroscopy

T2 - Application to tumors

AU - Liu, Hanli

AU - Gu, Yueqing

AU - Kim, Jae G.

AU - Mason, Ralph P.

PY - 2003

Y1 - 2003

N2 - Near Infrared (NIR) spectroscopy has been demonstrated as a new means to quantify oxygenation of tissue vasculature, in particular changes in hemoglobin concentrations and oxygen saturation. A novel application such oximetry to monitoring of tumor vascular oxygenation during respiratory interventions will be presented. Our recent results obtained with a one-channel NIR spectrometer observing rat breast and prostate tumors in vivo have demonstrated a biphasic response of tumor vascular oxygenation when the inhaled gas is switched from air to carbogen. We present a mathematical model associating the tumor vascular oxygenation to both well-perfused and poorly perfused regions in the tumor. Furthermore, laboratory phantom experiments and computational simulations using the Finite Element Method have been conducted to verify this tumor hemodynamic model.

AB - Near Infrared (NIR) spectroscopy has been demonstrated as a new means to quantify oxygenation of tissue vasculature, in particular changes in hemoglobin concentrations and oxygen saturation. A novel application such oximetry to monitoring of tumor vascular oxygenation during respiratory interventions will be presented. Our recent results obtained with a one-channel NIR spectrometer observing rat breast and prostate tumors in vivo have demonstrated a biphasic response of tumor vascular oxygenation when the inhaled gas is switched from air to carbogen. We present a mathematical model associating the tumor vascular oxygenation to both well-perfused and poorly perfused regions in the tumor. Furthermore, laboratory phantom experiments and computational simulations using the Finite Element Method have been conducted to verify this tumor hemodynamic model.

UR - http://www.scopus.com/inward/record.url?scp=8744262584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8744262584&partnerID=8YFLogxK

M3 - Conference contribution

VL - 88

SP - 198

EP - 201

BT - OSA Trends in Optics and Photonics Series

PB - Optical Society of American (OSA)

ER -