P53 ancestry: Gazing through an evolutionary lens

Wan Jin Lu, James F. Amatruda, John M. Abrams

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?

Original languageEnglish (US)
Pages (from-to)758-762
Number of pages5
JournalNature Reviews Cancer
Volume9
Issue number10
DOIs
StatePublished - Oct 2009

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Lenses
p53 Genes
Neoplasms
Genes
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

P53 ancestry : Gazing through an evolutionary lens. / Lu, Wan Jin; Amatruda, James F.; Abrams, John M.

In: Nature Reviews Cancer, Vol. 9, No. 10, 10.2009, p. 758-762.

Research output: Contribution to journalArticle

Lu, Wan Jin ; Amatruda, James F. ; Abrams, John M. / P53 ancestry : Gazing through an evolutionary lens. In: Nature Reviews Cancer. 2009 ; Vol. 9, No. 10. pp. 758-762.
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