P53 ancestry: Gazing through an evolutionary lens

Wan Jin Lu, James F. Amatruda, John M. Abrams

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?

Original languageEnglish (US)
Pages (from-to)758-762
Number of pages5
JournalNature Reviews Cancer
Volume9
Issue number10
DOIs
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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