TY - JOUR
T1 - Panorama
T2 - An integrated web-based sequence analysis tool and its role in gene discovery
AU - Pertsemlidis, Alexander
AU - Pande, Ashwini
AU - Miller, Brady
AU - Schilling, Peter
AU - Wei, Ming Hui
AU - Lerman, Michael I.
AU - Minna, John D.
AU - Garner, Harold R.
N1 - Funding Information:
We thank Hewlett-Packard for providing servers on which a large portion of this work was performed. This work was supported by the Whitaker Foundation, the P. O’B. Montgomery Distinguished Chair, National Cancer Institute Grants CA71618 and Lung Cancer SPORE P50 CA70907, the G. Harold and Leila Y. Mathers Charitable Foundation, and NIH Grant P50 HG01002-01. M.I.L. and M.H.W. (NCI) were funded in whole with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. NO1-CO-56000. The content of the publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. M.H.W. is now at Celera Genomics, Rockville, Maryland.
PY - 2000/12/15
Y1 - 2000/12/15
N2 - As the exponential growth of DNA sequence information in databases continues, the task of converting this deposited information into knowledge becomes more dependent on integrative sequence analysis and visualization tools. PANORAMA is an Internet-accessible software package that performs a variety of informatics analyses on a given DNA sequence and returns a visual and interactive representation of the results. Its design is modular, so that further sequence analysis tools can be integrated with minimal effort. The utility of PANORAMA is demonstrated in the analysis of 650 kb of human genomic DNA from chromosome region 3p21.3, a region of potential tumor suppressor genes involved in lung cancer, breast cancer, and other forms of cancer. PANORAMA aided in the discovery of genes and alternate splice forms of known exons, in the demarcation of intron - exon boundaries, and in the identification of promoter regions and polymorphisms, all of which contributed to a better understanding of the region. PANORAMA is available on the World Wide Web at http://atlas.swmed.edu.
AB - As the exponential growth of DNA sequence information in databases continues, the task of converting this deposited information into knowledge becomes more dependent on integrative sequence analysis and visualization tools. PANORAMA is an Internet-accessible software package that performs a variety of informatics analyses on a given DNA sequence and returns a visual and interactive representation of the results. Its design is modular, so that further sequence analysis tools can be integrated with minimal effort. The utility of PANORAMA is demonstrated in the analysis of 650 kb of human genomic DNA from chromosome region 3p21.3, a region of potential tumor suppressor genes involved in lung cancer, breast cancer, and other forms of cancer. PANORAMA aided in the discovery of genes and alternate splice forms of known exons, in the demarcation of intron - exon boundaries, and in the identification of promoter regions and polymorphisms, all of which contributed to a better understanding of the region. PANORAMA is available on the World Wide Web at http://atlas.swmed.edu.
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U2 - 10.1006/geno.2000.6359
DO - 10.1006/geno.2000.6359
M3 - Article
C2 - 11161780
AN - SCOPUS:0034671095
SN - 0888-7543
VL - 70
SP - 300
EP - 306
JO - Genomics
JF - Genomics
IS - 3
ER -