Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Mark Woods, Donald E. Woessner, A. Dean Sherry

Research output: Contribution to journalReview article

293 Scopus citations


This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.

Original languageEnglish (US)
Pages (from-to)500-511
Number of pages12
JournalChemical Society Reviews
Issue number6
StatePublished - Jun 7 2006


ASJC Scopus subject areas

  • Chemistry(all)

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