PARPs and ADP-Ribosylation

50 Years . . . and Counting

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Over 50 years ago, the discovery of poly(ADP-ribose) (PAR) set a new field of science in motion-the field of poly(ADP-ribosyl) transferases (PARPs) and ADP-ribosylation. The field is still flourishing today. The diversity of biological processes now known to require PARPs and ADP-ribosylation was practically unimaginable even two decades ago. From an initial focus on DNA damage detection and repair in response to genotoxic stresses, the field has expanded to include the regulation of chromatin structure, gene expression, and RNA processing in a wide range of biological systems, including reproduction, development, aging, stem cells, inflammation, metabolism, and cancer. This special focus issue of Molecular Cell includes a collection of three Reviews, three Perspectives, and a SnapShot, which together summarize the current state of the field and suggest where it may be headed.

Original languageEnglish (US)
Pages (from-to)902-910
Number of pages9
JournalMolecular Cell
Volume58
Issue number6
DOIs
StatePublished - Jun 18 2015

Fingerprint

Adenosine Diphosphate
DNA Damage
Poly Adenosine Diphosphate Ribose
Biological Phenomena
Transferases
DNA Repair
Chromatin
Reproduction
Stem Cells
RNA
Inflammation
Gene Expression
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

PARPs and ADP-Ribosylation : 50 Years . . . and Counting. / Kraus, W. Lee.

In: Molecular Cell, Vol. 58, No. 6, 18.06.2015, p. 902-910.

Research output: Contribution to journalArticle

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