Abstract
Acanthamoeba keratitis (AK†) is a rare but sight-threatening disease caused by pathogenic species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to contaminated water and ocular trauma are also associated with AK. Once a patient develops AK the prognosis is very poor unless an aggressive treatment regimen is initiated early. Some of the intriguing features of AK are the lack of immunological memory, resistance of the dormant cyst form to treatment, differences between the pathogenic strains and soil isolates of Acanthamoeba and the unique role of the innate immune system in controlling this disease. Understanding the series of steps involved in the pathogenesis of the disease and the host immune response against Acanthamoeba antigens is crucial for developing effective therapeutic strategies targeting the disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 261-268 |
| Number of pages | 8 |
| Journal | Yale Journal of Biology and Medicine |
| Volume | 90 |
| Issue number | 2 |
| State | Published - Jun 1 2017 |
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Keywords
- Acanthamoeba keratitis
- Corneal pathology
- Mucosal immunity
- Ocular immunology
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Pathobiology and immunobiology of Acanthamoeba keratitis : Insights from animal models. / Neelam, Sudha; Niederkorn, Jerry Y.
In: Yale Journal of Biology and Medicine, Vol. 90, No. 2, 01.06.2017, p. 261-268.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pathobiology and immunobiology of Acanthamoeba keratitis
T2 - Insights from animal models
AU - Neelam, Sudha
AU - Niederkorn, Jerry Y.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Acanthamoeba keratitis (AK†) is a rare but sight-threatening disease caused by pathogenic species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to contaminated water and ocular trauma are also associated with AK. Once a patient develops AK the prognosis is very poor unless an aggressive treatment regimen is initiated early. Some of the intriguing features of AK are the lack of immunological memory, resistance of the dormant cyst form to treatment, differences between the pathogenic strains and soil isolates of Acanthamoeba and the unique role of the innate immune system in controlling this disease. Understanding the series of steps involved in the pathogenesis of the disease and the host immune response against Acanthamoeba antigens is crucial for developing effective therapeutic strategies targeting the disease.
AB - Acanthamoeba keratitis (AK†) is a rare but sight-threatening disease caused by pathogenic species of Acanthamoeba. Despite its ubiquitous nature, the incidence of AK is relatively low compared to other forms of infectious keratitis. Although contact lens wear is a major risk factor, exposure to contaminated water and ocular trauma are also associated with AK. Once a patient develops AK the prognosis is very poor unless an aggressive treatment regimen is initiated early. Some of the intriguing features of AK are the lack of immunological memory, resistance of the dormant cyst form to treatment, differences between the pathogenic strains and soil isolates of Acanthamoeba and the unique role of the innate immune system in controlling this disease. Understanding the series of steps involved in the pathogenesis of the disease and the host immune response against Acanthamoeba antigens is crucial for developing effective therapeutic strategies targeting the disease.
KW - Acanthamoeba keratitis
KW - Corneal pathology
KW - Mucosal immunity
KW - Ocular immunology
UR - http://www.scopus.com/inward/record.url?scp=85021343029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021343029&partnerID=8YFLogxK
M3 - Review article
C2 - 28656012
AN - SCOPUS:85021343029
VL - 90
SP - 261
EP - 268
JO - Yale Journal of Biology and Medicine
JF - Yale Journal of Biology and Medicine
SN - 0044-0086
IS - 2
ER -