Pathological ventricular remodeling: Mechanisms: Part 1 of 2

Jana S. Burchfield, Min Xie, Joseph A Hill

Research output: Contribution to journalArticlepeer-review

355 Scopus citations

Abstract

Despite declines in heart failure morbidity and mortality with current therapies, rehospitalization rates remain distressingly high, substantially affecting individuals, society, and the economy. As a result, the need for new therapeutic advances and novel medical devices is urgent. Disease-related left ventricular remodeling is a complex process involving cardiac myocyte growth and death, vascular rarefaction, fibrosis, inflammation, and electrophysiological remodeling. Because these events are highly interrelated, targeting a single molecule or process may not be sufficient. Here, we review molecular and cellular mechanisms governing pathological ventricular remodeling.

Original languageEnglish (US)
Pages (from-to)388-400
Number of pages13
JournalCirculation
Volume128
Issue number4
DOIs
StatePublished - Jul 23 2013

Keywords

  • cardiac electrophysiology
  • fibrosis
  • inflammation
  • stem cells
  • ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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