Pathology of otitis media

C. G. Wright, W. L. Meyerhoff

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Otitis media is characterized by inflammation of the middle ear. The pathologic changes seen in this condition tend to occur on a continuum, progressing from acute and subacute stages to the chronic phase, in which irreversible tissue damage is observed. The earliest morphological changes involve the lamina propria of the middle ear mucosa and include increased capillary permeability, edema, and leukocytic infiltration. During the late acute to subacute stages, the mucosa also tends to show a marked increase in numbers of ciliated and secretory epithelial cells. As the inflammatory process enters the chronic phase, there is a continuing shift in the population of infiltrating leukocytes toward increasing numbers of mononuclear cells that secrete substances that facilitate tissue destruction and fibrosis. There is also development and proliferation of granulation tissue, which is intimately involved in the process of bone erosion. As granulation tissue matures, it becomes denser and less vascular - a process that leads to permanent fibrosis and formation of adhesions that may significantly compromise middle ear function. Other pathologic entities occasionally associated with chronic otitis media include cholesteatoma, cholesterol cysts and granuloma, and tympanosclerosis, all of which may contribute to irreversible alterations of middle ear structure.

Original languageEnglish (US)
Pages (from-to)24-26
Number of pages3
JournalAnnals of Otology, Rhinology and Laryngology
Volume103
Issue number5 II
StatePublished - 1994

Fingerprint

Otitis Media
Middle Ear
Mucous Membrane
Granulation Tissue
Pathology
Fibrosis
Myringosclerosis
Cholesteatoma
Capillary Permeability
Granuloma
Blood Vessels
Cysts
Edema
Leukocytes
Cell Count
Epithelial Cells
Cholesterol
Bone and Bones
Population

Keywords

  • inflammation
  • otitis media
  • pathology

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Wright, C. G., & Meyerhoff, W. L. (1994). Pathology of otitis media. Annals of Otology, Rhinology and Laryngology, 103(5 II), 24-26.

Pathology of otitis media. / Wright, C. G.; Meyerhoff, W. L.

In: Annals of Otology, Rhinology and Laryngology, Vol. 103, No. 5 II, 1994, p. 24-26.

Research output: Contribution to journalArticle

Wright, CG & Meyerhoff, WL 1994, 'Pathology of otitis media', Annals of Otology, Rhinology and Laryngology, vol. 103, no. 5 II, pp. 24-26.
Wright CG, Meyerhoff WL. Pathology of otitis media. Annals of Otology, Rhinology and Laryngology. 1994;103(5 II):24-26.
Wright, C. G. ; Meyerhoff, W. L. / Pathology of otitis media. In: Annals of Otology, Rhinology and Laryngology. 1994 ; Vol. 103, No. 5 II. pp. 24-26.
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