Pathophysiology of 'cold spot' and 'hot spot' myocardial imaging agents used to detect ischemia or infarction

L. M. Buja, R. W. Parkey, F. J. Bonte, J. T. Willerson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The purpose of this chapter is to summarize available information regarding the pathophysiological basis for the scintigraphic detection of ischemic and infarcted myocardium. Two general approaches have been developed: (1) negative ('cold spot') imaging with agents which concentrate in normal myocardium, and (2) positive ('hot spot') imaging with agents which concentrate in acutely infarcted myocardium. These two techniques for the detection of myocardial lesions are complimented by scintigraphic techniques which evaluate ventricular function and wall motion with agents which label the cardiac blood pool.

Original languageEnglish (US)
Pages (from-to)105-123
Number of pages19
JournalCardiovascular Clinics
Volume10
Issue number2
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Buja, L. M., Parkey, R. W., Bonte, F. J., & Willerson, J. T. (1979). Pathophysiology of 'cold spot' and 'hot spot' myocardial imaging agents used to detect ischemia or infarction. Cardiovascular Clinics, 10(2), 105-123.