Patrilocal* * patrilocal: taking the bride to the husband's home village cell-cell interactions: sevenless captures its bride

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Development of the R7 neuron in the compound eye of Drosophila requires an inductive interaction between the R8 photoreceptor cell and the bipotential R7 precursor cell. Two transmembrane proteins mediate this induction: sevenless (sev), a receptor tyrosine kinase expressed on the apical surface of the R7 precursor cell, and its ligand, the bride of sevenless protein (boss) on the apical membrane of the R8 neuron. The boss protein, with its large extracellular domain and seven transmembrane segments, is an unusual ligand for a receptor tyrosine kinase, and its internalization into the R7 cell following interaction with sev is particularly intriguing.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalTrends in Cell Biology
Volume3
Issue number4
DOIs
StatePublished - Apr 1993

ASJC Scopus subject areas

  • Cell Biology

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