Patrilocal* * patrilocal: taking the bride to the husband's home village cell-cell interactions: sevenless captures its bride

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Abstract

Development of the R7 neuron in the compound eye of Drosophila requires an inductive interaction between the R8 photoreceptor cell and the bipotential R7 precursor cell. Two transmembrane proteins mediate this induction: sevenless (sev), a receptor tyrosine kinase expressed on the apical surface of the R7 precursor cell, and its ligand, the bride of sevenless protein (boss) on the apical membrane of the R8 neuron. The boss protein, with its large extracellular domain and seven transmembrane segments, is an unusual ligand for a receptor tyrosine kinase, and its internalization into the R7 cell following interaction with sev is particularly intriguing.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalTrends in Cell Biology
Volume3
Issue number4
DOIs
StatePublished - 1993

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Spouses
Cell Communication
Receptor Protein-Tyrosine Kinases
Ligands
Neurons
Photoreceptor Cells
Proteins
Drosophila
Membranes

ASJC Scopus subject areas

  • Cell Biology

Cite this

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AB - Development of the R7 neuron in the compound eye of Drosophila requires an inductive interaction between the R8 photoreceptor cell and the bipotential R7 precursor cell. Two transmembrane proteins mediate this induction: sevenless (sev), a receptor tyrosine kinase expressed on the apical surface of the R7 precursor cell, and its ligand, the bride of sevenless protein (boss) on the apical membrane of the R8 neuron. The boss protein, with its large extracellular domain and seven transmembrane segments, is an unusual ligand for a receptor tyrosine kinase, and its internalization into the R7 cell following interaction with sev is particularly intriguing.

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