Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Lei Du, Kefei Liu, Xiaohui Yao, Jingwen Yan, Shannon L. Risacher, Junwei Han, Lei Guo, Andrew J. Saykin, Li Shen, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw & 293 others Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Archana B. Balasubramanian, Jennifer Mason, Iris Sim, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J. Cairns, Erin Franklin, Lisa Taylor-Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M. Foroud, Steven Potkin, Kelley Faber, Sungeun Kim, Kwangsik Nho, Leon Thal, Neil Buckholtz, Marilyn Albert, Richard Frank, John Hsiao, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva-Meyer, Valory Pavlik, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau Ances, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla Detoledo-Morrell, Ranjan Duara, Maria T. Greig-Custo, Warren Barker, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, Martin Sadowski, Mohammed O. Sheikh, Anaztasia Ulysse, Mrunalini Gaikwad, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges-Neto, Terence Z. Wong, Edward Coleman, Steven E. Arnold, Jason H. Karlawish, David A. Wolk, Christopher M. Clark, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L. Lopez, Mary Ann Oakley, Donna M. Simpson, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Adrian Preda, Dana Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H.S. Silverman, Po H. Lu, George Bartzokis, Neill R. Graff-Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. Van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra Black, Bojana Stefanovic, Curtis Caldwell, Ging Yuek Robin Hsiung, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, John Rogers, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Emily Rogalski, Kristine Lipowski, Sandra Weintraub, Borna Bonakdarpour, Diana Kerwin, Chuang Kuo Wu, Nancy Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Jerome Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Evan Fletcher, Pauline Maillard, John Olichney, Charles Decarli, Owen Carmichael, Smita Kittur, Michael Borrie, T. Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Pierre Tariot, Anna Burke, Ann Marie Milliken, Nadira Trncic, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Brendan Kelly, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Leslie Gordineer, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Geoffrey Tremont, Lori A. Daiello, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, David Perry, Jacobo Mintzer, Kenneth Spicer, David Bachman, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K. Schultz, Karen Ekstam Smith, Hristina Koleva, Ki Won Nam, Hyungsub Shim, Norman Relkin, Gloria Chaing, Michael Lin, Lisa Ravdin, Amanda Smith, Balebail Ashok Raj, Kristin Fargher

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only convex, but also singular at the origin, which is a necessary condition for sparsity. Thus most SCCA methods impose ℓ 1 -norm onto the individual feature or the structure level of features to pursuit corresponding sparsity. However, the ℓ1 -norm penalty over-penalizes large coefficients and may incurs estimation bias. A number of non-convex penalties are proposed to reduce the estimation bias in regression tasks. But using them in SCCA remains largely unexplored. In this paper, we design a unified non-convex SCCA model, based on seven non-convex functions, for unbiased estimation and stable feature selection simultaneously. We also propose an efficient optimization algorithm. The proposed method obtains both higher correlation coefficients and better canonical loading patterns. Specifically, these SCCA methods with non-convex penalties discover a strong association between the APOE e4 rs429358 SNP and the hippocampus region of the brain. They both are Alzheimer's disease related biomarkers, indicating the potential and power of the non-convex methods in brain imaging genetics.

Original languageEnglish (US)
Article number14052
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

Fingerprint

Neuroimaging
Genetic Markers
Single Nucleotide Polymorphism
Hippocampus
Alzheimer Disease
Biomarkers
Brain

ASJC Scopus subject areas

  • General

Cite this

Du, L., Liu, K., Yao, X., Yan, J., Risacher, S. L., Han, J., ... Fargher, K. (2017). Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty. Scientific Reports, 7(1), [14052]. https://doi.org/10.1038/s41598-017-13930-y

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty. / Du, Lei; Liu, Kefei; Yao, Xiaohui; Yan, Jingwen; Risacher, Shannon L.; Han, Junwei; Guo, Lei; Saykin, Andrew J.; Shen, Li; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Carrillo, Maria; Kuller, Lew; Raichle, Marc; Paul, Steven; Davies, Peter; Fillit, Howard; Hefti, Franz; Holtzman, David; Mesulam, M. Marcel; Potter, William; Snyder, Peter; Schwartz, Adam; Montine, Tom; Thomas, Ronald G.; Donohue, Michael; Walter, Sarah; Gessert, Devon; Sather, Tamie; Jiminez, Gus; Balasubramanian, Archana B.; Mason, Jennifer; Sim, Iris; Harvey, Danielle; Bernstein, Matthew; Fox, Nick; Thompson, Paul; Schuff, Norbert; Decarli, Charles; Borowski, Bret; Gunter, Jeff; Senjem, Matt; Vemuri, Prashanthi; Jones, David; Kantarci, Kejal; Ward, Chad; Koeppe, Robert A.; Foster, Norm; Reiman, Eric M.; Chen, Kewei; Mathis, Chet; Landau, Susan; Cairns, Nigel J.; Franklin, Erin; Taylor-Reinwald, Lisa; Lee, Virginia; Korecka, Magdalena; Figurski, Michal; Crawford, Karen; Neu, Scott; Foroud, Tatiana M.; Potkin, Steven; Faber, Kelley; Kim, Sungeun; Nho, Kwangsik; Thal, Leon; Buckholtz, Neil; Albert, Marilyn; Frank, Richard; Hsiao, John; Kaye, Jeffrey; Quinn, Joseph; Silbert, Lisa; Lind, Betty; Carter, Raina; Dolen, Sara; Schneider, Lon S.; Pawluczyk, Sonia; Beccera, Mauricio; Teodoro, Liberty; Spann, Bryan M.; Brewer, James; Vanderswag, Helen; Fleisher, Adam; Heidebrink, Judith L.; Lord, Joanne L.; Mason, Sara S.; Albers, Colleen S.; Knopman, David; Johnson, Kris; Doody, Rachelle S.; Villanueva-Meyer, Javier; Pavlik, Valory; Shibley, Victoria; Chowdhury, Munir; Rountree, Susan; Dang, Mimi; Stern, Yaakov; Honig, Lawrence S.; Bell, Karen L.; Ances, Beau; Carroll, Maria; Creech, Mary L.; Franklin, Erin; Mintun, Mark A.; Schneider, Stacy; Oliver, Angela; Marson, Daniel; Geldmacher, David; Love, Marissa Natelson; Griffith, Randall; Clark, David; Brockington, John; Roberson, Erik; Grossman, Hillel; Mitsis, Effie; Shah, Raj C.; Detoledo-Morrell, Leyla; Duara, Ranjan; Greig-Custo, Maria T.; Barker, Warren; Onyike, Chiadi; D'Agostino, Daniel; Kielb, Stephanie; Sadowski, Martin; Sheikh, Mohammed O.; Ulysse, Anaztasia; Gaikwad, Mrunalini; Murali Doraiswamy, P.; Petrella, Jeffrey R.; Borges-Neto, Salvador; Wong, Terence Z.; Coleman, Edward; Arnold, Steven E.; Karlawish, Jason H.; Wolk, David A.; Clark, Christopher M.; Smith, Charles D.; Jicha, Greg; Hardy, Peter; Sinha, Partha; Oates, Elizabeth; Conrad, Gary; Lopez, Oscar L.; Oakley, Mary Ann; Simpson, Donna M.; Porsteinsson, Anton P.; Goldstein, Bonnie S.; Martin, Kim; Makino, Kelly M.; Ismail, M. Saleem; Brand, Connie; Preda, Adrian; Nguyen, Dana; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Levey, Allan I.; Lah, James J.; Cellar, Janet S.; Burns, Jeffrey M.; Swerdlow, Russell H.; Brooks, William M.; Apostolova, Liana; Tingus, Kathleen; Woo, Ellen; Silverman, Daniel H.S.; Lu, Po H.; Bartzokis, George; Graff-Radford, Neill R.; Parfitt, Francine; Poki-Walker, Kim; Farlow, Martin R.; Marie Hake, Ann; Matthews, Brandy R.; Brosch, Jared R.; Herring, Scott; Van Dyck, Christopher H.; Carson, Richard E.; MacAvoy, Martha G.; Varma, Pradeep; Chertkow, Howard; Bergman, Howard; Hosein, Chris; Black, Sandra; Stefanovic, Bojana; Caldwell, Curtis; Robin Hsiung, Ging Yuek; Mudge, Benita; Sossi, Vesna; Feldman, Howard; Assaly, Michele; Finger, Elizabeth; Pasternack, Stephen; Rachisky, Irina; Rogers, John; Trost, Dick; Kertesz, Andrew; Bernick, Charles; Munic, Donna; Rogalski, Emily; Lipowski, Kristine; Weintraub, Sandra; Bonakdarpour, Borna; Kerwin, Diana; Wu, Chuang Kuo; Johnson, Nancy; Sadowsky, Carl; Villena, Teresa; Scott Turner, Raymond; Johnson, Kathleen; Reynolds, Brigid; Sperling, Reisa A.; Johnson, Keith A.; Marshall, Gad; Yesavage, Jerome; Taylor, Joy L.; Lane, Barton; Rosen, Allyson; Tinklenberg, Jared; Sabbagh, Marwan N.; Belden, Christine M.; Jacobson, Sandra A.; Sirrel, Sherye A.; Kowall, Neil; Killiany, Ronald; Budson, Andrew E.; Norbash, Alexander; Lynn Johnson, Patricia; Obisesan, Thomas O.; Wolday, Saba; Allard, Joanne; Lerner, Alan; Ogrocki, Paula; Tatsuoka, Curtis; Fatica, Parianne; Fletcher, Evan; Maillard, Pauline; Olichney, John; Decarli, Charles; Carmichael, Owen; Kittur, Smita; Borrie, Michael; Lee, T. Y.; Bartha, Rob; Johnson, Sterling; Asthana, Sanjay; Carlsson, Cynthia M.; Tariot, Pierre; Burke, Anna; Milliken, Ann Marie; Trncic, Nadira; Fleisher, Adam; Reeder, Stephanie; Bates, Vernice; Capote, Horacio; Rainka, Michelle; Scharre, Douglas W.; Kataki, Maria; Kelly, Brendan; Zimmerman, Earl A.; Celmins, Dzintra; Brown, Alice D.; Pearlson, Godfrey D.; Blank, Karen; Anderson, Karen; Flashman, Laura A.; Seltzer, Marc; Hynes, Mary L.; Santulli, Robert B.; Sink, Kaycee M.; Gordineer, Leslie; Williamson, Jeff D.; Garg, Pradeep; Watkins, Franklin; Ott, Brian R.; Tremont, Geoffrey; Daiello, Lori A.; Salloway, Stephen; Malloy, Paul; Correia, Stephen; Rosen, Howard J.; Miller, Bruce L.; Perry, David; Mintzer, Jacobo; Spicer, Kenneth; Bachman, David; Pomara, Nunzio; Hernando, Raymundo; Sarrael, Antero; Schultz, Susan K.; Ekstam Smith, Karen; Koleva, Hristina; Nam, Ki Won; Shim, Hyungsub; Relkin, Norman; Chaing, Gloria; Lin, Michael; Ravdin, Lisa; Smith, Amanda; Ashok Raj, Balebail; Fargher, Kristin.

In: Scientific Reports, Vol. 7, No. 1, 14052, 01.12.2017.

Research output: Contribution to journalArticle

Du, L, Liu, K, Yao, X, Yan, J, Risacher, SL, Han, J, Guo, L, Saykin, AJ, Shen, L, Weiner, MW, Aisen, P, Petersen, R, Jack, CR, Jagust, W, Trojanowki, JQ, Toga, AW, Beckett, L, Green, RC, Morris, J, Shaw, LM, Khachaturian, Z, Sorensen, G, Carrillo, M, Kuller, L, Raichle, M, Paul, S, Davies, P, Fillit, H, Hefti, F, Holtzman, D, Mesulam, MM, Potter, W, Snyder, P, Schwartz, A, Montine, T, Thomas, RG, Donohue, M, Walter, S, Gessert, D, Sather, T, Jiminez, G, Balasubramanian, AB, Mason, J, Sim, I, Harvey, D, Bernstein, M, Fox, N, Thompson, P, Schuff, N, Decarli, C, Borowski, B, Gunter, J, Senjem, M, Vemuri, P, Jones, D, Kantarci, K, Ward, C, Koeppe, RA, Foster, N, Reiman, EM, Chen, K, Mathis, C, Landau, S, Cairns, NJ, Franklin, E, Taylor-Reinwald, L, Lee, V, Korecka, M, Figurski, M, Crawford, K, Neu, S, Foroud, TM, Potkin, S, Faber, K, Kim, S, Nho, K, Thal, L, Buckholtz, N, Albert, M, Frank, R, Hsiao, J, Kaye, J, Quinn, J, Silbert, L, Lind, B, Carter, R, Dolen, S, Schneider, LS, Pawluczyk, S, Beccera, M, Teodoro, L, Spann, BM, Brewer, J, Vanderswag, H, Fleisher, A, Heidebrink, JL, Lord, JL, Mason, SS, Albers, CS, Knopman, D, Johnson, K, Doody, RS, Villanueva-Meyer, J, Pavlik, V, Shibley, V, Chowdhury, M, Rountree, S, Dang, M, Stern, Y, Honig, LS, Bell, KL, Ances, B, Carroll, M, Creech, ML, Franklin, E, Mintun, MA, Schneider, S, Oliver, A, Marson, D, Geldmacher, D, Love, MN, Griffith, R, Clark, D, Brockington, J, Roberson, E, Grossman, H, Mitsis, E, Shah, RC, Detoledo-Morrell, L, Duara, R, Greig-Custo, MT, Barker, W, Onyike, C, D'Agostino, D, Kielb, S, Sadowski, M, Sheikh, MO, Ulysse, A, Gaikwad, M, Murali Doraiswamy, P, Petrella, JR, Borges-Neto, S, Wong, TZ, Coleman, E, Arnold, SE, Karlawish, JH, Wolk, DA, Clark, CM, Smith, CD, Jicha, G, Hardy, P, Sinha, P, Oates, E, Conrad, G, Lopez, OL, Oakley, MA, Simpson, DM, Porsteinsson, AP, Goldstein, BS, Martin, K, Makino, KM, Ismail, MS, Brand, C, Preda, A, Nguyen, D, Womack, K, Mathews, D, Quiceno, M, Levey, AI, Lah, JJ, Cellar, JS, Burns, JM, Swerdlow, RH, Brooks, WM, Apostolova, L, Tingus, K, Woo, E, Silverman, DHS, Lu, PH, Bartzokis, G, Graff-Radford, NR, Parfitt, F, Poki-Walker, K, Farlow, MR, Marie Hake, A, Matthews, BR, Brosch, JR, Herring, S, Van Dyck, CH, Carson, RE, MacAvoy, MG, Varma, P, Chertkow, H, Bergman, H, Hosein, C, Black, S, Stefanovic, B, Caldwell, C, Robin Hsiung, GY, Mudge, B, Sossi, V, Feldman, H, Assaly, M, Finger, E, Pasternack, S, Rachisky, I, Rogers, J, Trost, D, Kertesz, A, Bernick, C, Munic, D, Rogalski, E, Lipowski, K, Weintraub, S, Bonakdarpour, B, Kerwin, D, Wu, CK, Johnson, N, Sadowsky, C, Villena, T, Scott Turner, R, Johnson, K, Reynolds, B, Sperling, RA, Johnson, KA, Marshall, G, Yesavage, J, Taylor, JL, Lane, B, Rosen, A, Tinklenberg, J, Sabbagh, MN, Belden, CM, Jacobson, SA, Sirrel, SA, Kowall, N, Killiany, R, Budson, AE, Norbash, A, Lynn Johnson, P, Obisesan, TO, Wolday, S, Allard, J, Lerner, A, Ogrocki, P, Tatsuoka, C, Fatica, P, Fletcher, E, Maillard, P, Olichney, J, Decarli, C, Carmichael, O, Kittur, S, Borrie, M, Lee, TY, Bartha, R, Johnson, S, Asthana, S, Carlsson, CM, Tariot, P, Burke, A, Milliken, AM, Trncic, N, Fleisher, A, Reeder, S, Bates, V, Capote, H, Rainka, M, Scharre, DW, Kataki, M, Kelly, B, Zimmerman, EA, Celmins, D, Brown, AD, Pearlson, GD, Blank, K, Anderson, K, Flashman, LA, Seltzer, M, Hynes, ML, Santulli, RB, Sink, KM, Gordineer, L, Williamson, JD, Garg, P, Watkins, F, Ott, BR, Tremont, G, Daiello, LA, Salloway, S, Malloy, P, Correia, S, Rosen, HJ, Miller, BL, Perry, D, Mintzer, J, Spicer, K, Bachman, D, Pomara, N, Hernando, R, Sarrael, A, Schultz, SK, Ekstam Smith, K, Koleva, H, Nam, KW, Shim, H, Relkin, N, Chaing, G, Lin, M, Ravdin, L, Smith, A, Ashok Raj, B & Fargher, K 2017, 'Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty', Scientific Reports, vol. 7, no. 1, 14052. https://doi.org/10.1038/s41598-017-13930-y
Du, Lei ; Liu, Kefei ; Yao, Xiaohui ; Yan, Jingwen ; Risacher, Shannon L. ; Han, Junwei ; Guo, Lei ; Saykin, Andrew J. ; Shen, Li ; Weiner, Michael W. ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford R. ; Jagust, William ; Trojanowki, John Q. ; Toga, Arthur W. ; Beckett, Laurel ; Green, Robert C. ; Morris, John ; Shaw, Leslie M. ; Khachaturian, Zaven ; Sorensen, Greg ; Carrillo, Maria ; Kuller, Lew ; Raichle, Marc ; Paul, Steven ; Davies, Peter ; Fillit, Howard ; Hefti, Franz ; Holtzman, David ; Mesulam, M. Marcel ; Potter, William ; Snyder, Peter ; Schwartz, Adam ; Montine, Tom ; Thomas, Ronald G. ; Donohue, Michael ; Walter, Sarah ; Gessert, Devon ; Sather, Tamie ; Jiminez, Gus ; Balasubramanian, Archana B. ; Mason, Jennifer ; Sim, Iris ; Harvey, Danielle ; Bernstein, Matthew ; Fox, Nick ; Thompson, Paul ; Schuff, Norbert ; Decarli, Charles ; Borowski, Bret ; Gunter, Jeff ; Senjem, Matt ; Vemuri, Prashanthi ; Jones, David ; Kantarci, Kejal ; Ward, Chad ; Koeppe, Robert A. ; Foster, Norm ; Reiman, Eric M. ; Chen, Kewei ; Mathis, Chet ; Landau, Susan ; Cairns, Nigel J. ; Franklin, Erin ; Taylor-Reinwald, Lisa ; Lee, Virginia ; Korecka, Magdalena ; Figurski, Michal ; Crawford, Karen ; Neu, Scott ; Foroud, Tatiana M. ; Potkin, Steven ; Faber, Kelley ; Kim, Sungeun ; Nho, Kwangsik ; Thal, Leon ; Buckholtz, Neil ; Albert, Marilyn ; Frank, Richard ; Hsiao, John ; Kaye, Jeffrey ; Quinn, Joseph ; Silbert, Lisa ; Lind, Betty ; Carter, Raina ; Dolen, Sara ; Schneider, Lon S. ; Pawluczyk, Sonia ; Beccera, Mauricio ; Teodoro, Liberty ; Spann, Bryan M. ; Brewer, James ; Vanderswag, Helen ; Fleisher, Adam ; Heidebrink, Judith L. ; Lord, Joanne L. ; Mason, Sara S. ; Albers, Colleen S. ; Knopman, David ; Johnson, Kris ; Doody, Rachelle S. ; Villanueva-Meyer, Javier ; Pavlik, Valory ; Shibley, Victoria ; Chowdhury, Munir ; Rountree, Susan ; Dang, Mimi ; Stern, Yaakov ; Honig, Lawrence S. ; Bell, Karen L. ; Ances, Beau ; Carroll, Maria ; Creech, Mary L. ; Franklin, Erin ; Mintun, Mark A. ; Schneider, Stacy ; Oliver, Angela ; Marson, Daniel ; Geldmacher, David ; Love, Marissa Natelson ; Griffith, Randall ; Clark, David ; Brockington, John ; Roberson, Erik ; Grossman, Hillel ; Mitsis, Effie ; Shah, Raj C. ; Detoledo-Morrell, Leyla ; Duara, Ranjan ; Greig-Custo, Maria T. ; Barker, Warren ; Onyike, Chiadi ; D'Agostino, Daniel ; Kielb, Stephanie ; Sadowski, Martin ; Sheikh, Mohammed O. ; Ulysse, Anaztasia ; Gaikwad, Mrunalini ; Murali Doraiswamy, P. ; Petrella, Jeffrey R. ; Borges-Neto, Salvador ; Wong, Terence Z. ; Coleman, Edward ; Arnold, Steven E. ; Karlawish, Jason H. ; Wolk, David A. ; Clark, Christopher M. ; Smith, Charles D. ; Jicha, Greg ; Hardy, Peter ; Sinha, Partha ; Oates, Elizabeth ; Conrad, Gary ; Lopez, Oscar L. ; Oakley, Mary Ann ; Simpson, Donna M. ; Porsteinsson, Anton P. ; Goldstein, Bonnie S. ; Martin, Kim ; Makino, Kelly M. ; Ismail, M. Saleem ; Brand, Connie ; Preda, Adrian ; Nguyen, Dana ; Womack, Kyle ; Mathews, Dana ; Quiceno, Mary ; Levey, Allan I. ; Lah, James J. ; Cellar, Janet S. ; Burns, Jeffrey M. ; Swerdlow, Russell H. ; Brooks, William M. ; Apostolova, Liana ; Tingus, Kathleen ; Woo, Ellen ; Silverman, Daniel H.S. ; Lu, Po H. ; Bartzokis, George ; Graff-Radford, Neill R. ; Parfitt, Francine ; Poki-Walker, Kim ; Farlow, Martin R. ; Marie Hake, Ann ; Matthews, Brandy R. ; Brosch, Jared R. ; Herring, Scott ; Van Dyck, Christopher H. ; Carson, Richard E. ; MacAvoy, Martha G. ; Varma, Pradeep ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Stefanovic, Bojana ; Caldwell, Curtis ; Robin Hsiung, Ging Yuek ; Mudge, Benita ; Sossi, Vesna ; Feldman, Howard ; Assaly, Michele ; Finger, Elizabeth ; Pasternack, Stephen ; Rachisky, Irina ; Rogers, John ; Trost, Dick ; Kertesz, Andrew ; Bernick, Charles ; Munic, Donna ; Rogalski, Emily ; Lipowski, Kristine ; Weintraub, Sandra ; Bonakdarpour, Borna ; Kerwin, Diana ; Wu, Chuang Kuo ; Johnson, Nancy ; Sadowsky, Carl ; Villena, Teresa ; Scott Turner, Raymond ; Johnson, Kathleen ; Reynolds, Brigid ; Sperling, Reisa A. ; Johnson, Keith A. ; Marshall, Gad ; Yesavage, Jerome ; Taylor, Joy L. ; Lane, Barton ; Rosen, Allyson ; Tinklenberg, Jared ; Sabbagh, Marwan N. ; Belden, Christine M. ; Jacobson, Sandra A. ; Sirrel, Sherye A. ; Kowall, Neil ; Killiany, Ronald ; Budson, Andrew E. ; Norbash, Alexander ; Lynn Johnson, Patricia ; Obisesan, Thomas O. ; Wolday, Saba ; Allard, Joanne ; Lerner, Alan ; Ogrocki, Paula ; Tatsuoka, Curtis ; Fatica, Parianne ; Fletcher, Evan ; Maillard, Pauline ; Olichney, John ; Decarli, Charles ; Carmichael, Owen ; Kittur, Smita ; Borrie, Michael ; Lee, T. Y. ; Bartha, Rob ; Johnson, Sterling ; Asthana, Sanjay ; Carlsson, Cynthia M. ; Tariot, Pierre ; Burke, Anna ; Milliken, Ann Marie ; Trncic, Nadira ; Fleisher, Adam ; Reeder, Stephanie ; Bates, Vernice ; Capote, Horacio ; Rainka, Michelle ; Scharre, Douglas W. ; Kataki, Maria ; Kelly, Brendan ; Zimmerman, Earl A. ; Celmins, Dzintra ; Brown, Alice D. ; Pearlson, Godfrey D. ; Blank, Karen ; Anderson, Karen ; Flashman, Laura A. ; Seltzer, Marc ; Hynes, Mary L. ; Santulli, Robert B. ; Sink, Kaycee M. ; Gordineer, Leslie ; Williamson, Jeff D. ; Garg, Pradeep ; Watkins, Franklin ; Ott, Brian R. ; Tremont, Geoffrey ; Daiello, Lori A. ; Salloway, Stephen ; Malloy, Paul ; Correia, Stephen ; Rosen, Howard J. ; Miller, Bruce L. ; Perry, David ; Mintzer, Jacobo ; Spicer, Kenneth ; Bachman, David ; Pomara, Nunzio ; Hernando, Raymundo ; Sarrael, Antero ; Schultz, Susan K. ; Ekstam Smith, Karen ; Koleva, Hristina ; Nam, Ki Won ; Shim, Hyungsub ; Relkin, Norman ; Chaing, Gloria ; Lin, Michael ; Ravdin, Lisa ; Smith, Amanda ; Ashok Raj, Balebail ; Fargher, Kristin. / Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
@article{0f72efe0d7954576b5f49ea71d10cd13,
title = "Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty",
abstract = "Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only convex, but also singular at the origin, which is a necessary condition for sparsity. Thus most SCCA methods impose ℓ 1 -norm onto the individual feature or the structure level of features to pursuit corresponding sparsity. However, the ℓ1 -norm penalty over-penalizes large coefficients and may incurs estimation bias. A number of non-convex penalties are proposed to reduce the estimation bias in regression tasks. But using them in SCCA remains largely unexplored. In this paper, we design a unified non-convex SCCA model, based on seven non-convex functions, for unbiased estimation and stable feature selection simultaneously. We also propose an efficient optimization algorithm. The proposed method obtains both higher correlation coefficients and better canonical loading patterns. Specifically, these SCCA methods with non-convex penalties discover a strong association between the APOE e4 rs429358 SNP and the hippocampus region of the brain. They both are Alzheimer's disease related biomarkers, indicating the potential and power of the non-convex methods in brain imaging genetics.",
author = "Lei Du and Kefei Liu and Xiaohui Yao and Jingwen Yan and Risacher, {Shannon L.} and Junwei Han and Lei Guo and Saykin, {Andrew J.} and Li Shen and Weiner, {Michael W.} and Paul Aisen and Ronald Petersen and Jack, {Clifford R.} and William Jagust and Trojanowki, {John Q.} and Toga, {Arthur W.} and Laurel Beckett and Green, {Robert C.} and John Morris and Shaw, {Leslie M.} and Zaven Khachaturian and Greg Sorensen and Maria Carrillo and Lew Kuller and Marc Raichle and Steven Paul and Peter Davies and Howard Fillit and Franz Hefti and David Holtzman and Mesulam, {M. Marcel} and William Potter and Peter Snyder and Adam Schwartz and Tom Montine and Thomas, {Ronald G.} and Michael Donohue and Sarah Walter and Devon Gessert and Tamie Sather and Gus Jiminez and Balasubramanian, {Archana B.} and Jennifer Mason and Iris Sim and Danielle Harvey and Matthew Bernstein and Nick Fox and Paul Thompson and Norbert Schuff and Charles Decarli and Bret Borowski and Jeff Gunter and Matt Senjem and Prashanthi Vemuri and David Jones and Kejal Kantarci and Chad Ward and Koeppe, {Robert A.} and Norm Foster and Reiman, {Eric M.} and Kewei Chen and Chet Mathis and Susan Landau and Cairns, {Nigel J.} and Erin Franklin and Lisa Taylor-Reinwald and Virginia Lee and Magdalena Korecka and Michal Figurski and Karen Crawford and Scott Neu and Foroud, {Tatiana M.} and Steven Potkin and Kelley Faber and Sungeun Kim and Kwangsik Nho and Leon Thal and Neil Buckholtz and Marilyn Albert and Richard Frank and John Hsiao and Jeffrey Kaye and Joseph Quinn and Lisa Silbert and Betty Lind and Raina Carter and Sara Dolen and Schneider, {Lon S.} and Sonia Pawluczyk and Mauricio Beccera and Liberty Teodoro and Spann, {Bryan M.} and James Brewer and Helen Vanderswag and Adam Fleisher and Heidebrink, {Judith L.} and Lord, {Joanne L.} and Mason, {Sara S.} and Albers, {Colleen S.} and David Knopman and Kris Johnson and Doody, {Rachelle S.} and Javier Villanueva-Meyer and Valory Pavlik and Victoria Shibley and Munir Chowdhury and Susan Rountree and Mimi Dang and Yaakov Stern and Honig, {Lawrence S.} and Bell, {Karen L.} and Beau Ances and Maria Carroll and Creech, {Mary L.} and Erin Franklin and Mintun, {Mark A.} and Stacy Schneider and Angela Oliver and Daniel Marson and David Geldmacher and Love, {Marissa Natelson} and Randall Griffith and David Clark and John Brockington and Erik Roberson and Hillel Grossman and Effie Mitsis and Shah, {Raj C.} and Leyla Detoledo-Morrell and Ranjan Duara and Greig-Custo, {Maria T.} and Warren Barker and Chiadi Onyike and Daniel D'Agostino and Stephanie Kielb and Martin Sadowski and Sheikh, {Mohammed O.} and Anaztasia Ulysse and Mrunalini Gaikwad and {Murali Doraiswamy}, P. and Petrella, {Jeffrey R.} and Salvador Borges-Neto and Wong, {Terence Z.} and Edward Coleman and Arnold, {Steven E.} and Karlawish, {Jason H.} and Wolk, {David A.} and Clark, {Christopher M.} and Smith, {Charles D.} and Greg Jicha and Peter Hardy and Partha Sinha and Elizabeth Oates and Gary Conrad and Lopez, {Oscar L.} and Oakley, {Mary Ann} and Simpson, {Donna M.} and Porsteinsson, {Anton P.} and Goldstein, {Bonnie S.} and Kim Martin and Makino, {Kelly M.} and Ismail, {M. Saleem} and Connie Brand and Adrian Preda and Dana Nguyen and Kyle Womack and Dana Mathews and Mary Quiceno and Levey, {Allan I.} and Lah, {James J.} and Cellar, {Janet S.} and Burns, {Jeffrey M.} and Swerdlow, {Russell H.} and Brooks, {William M.} and Liana Apostolova and Kathleen Tingus and Ellen Woo and Silverman, {Daniel H.S.} and Lu, {Po H.} and George Bartzokis and Graff-Radford, {Neill R.} and Francine Parfitt and Kim Poki-Walker and Farlow, {Martin R.} and {Marie Hake}, Ann and Matthews, {Brandy R.} and Brosch, {Jared R.} and Scott Herring and {Van Dyck}, {Christopher H.} and Carson, {Richard E.} and MacAvoy, {Martha G.} and Pradeep Varma and Howard Chertkow and Howard Bergman and Chris Hosein and Sandra Black and Bojana Stefanovic and Curtis Caldwell and {Robin Hsiung}, {Ging Yuek} and Benita Mudge and Vesna Sossi and Howard Feldman and Michele Assaly and Elizabeth Finger and Stephen Pasternack and Irina Rachisky and John Rogers and Dick Trost and Andrew Kertesz and Charles Bernick and Donna Munic and Emily Rogalski and Kristine Lipowski and Sandra Weintraub and Borna Bonakdarpour and Diana Kerwin and Wu, {Chuang Kuo} and Nancy Johnson and Carl Sadowsky and Teresa Villena and {Scott Turner}, Raymond and Kathleen Johnson and Brigid Reynolds and Sperling, {Reisa A.} and Johnson, {Keith A.} and Gad Marshall and Jerome Yesavage and Taylor, {Joy L.} and Barton Lane and Allyson Rosen and Jared Tinklenberg and Sabbagh, {Marwan N.} and Belden, {Christine M.} and Jacobson, {Sandra A.} and Sirrel, {Sherye A.} and Neil Kowall and Ronald Killiany and Budson, {Andrew E.} and Alexander Norbash and {Lynn Johnson}, Patricia and Obisesan, {Thomas O.} and Saba Wolday and Joanne Allard and Alan Lerner and Paula Ogrocki and Curtis Tatsuoka and Parianne Fatica and Evan Fletcher and Pauline Maillard and John Olichney and Charles Decarli and Owen Carmichael and Smita Kittur and Michael Borrie and Lee, {T. Y.} and Rob Bartha and Sterling Johnson and Sanjay Asthana and Carlsson, {Cynthia M.} and Pierre Tariot and Anna Burke and Milliken, {Ann Marie} and Nadira Trncic and Adam Fleisher and Stephanie Reeder and Vernice Bates and Horacio Capote and Michelle Rainka and Scharre, {Douglas W.} and Maria Kataki and Brendan Kelly and Zimmerman, {Earl A.} and Dzintra Celmins and Brown, {Alice D.} and Pearlson, {Godfrey D.} and Karen Blank and Karen Anderson and Flashman, {Laura A.} and Marc Seltzer and Hynes, {Mary L.} and Santulli, {Robert B.} and Sink, {Kaycee M.} and Leslie Gordineer and Williamson, {Jeff D.} and Pradeep Garg and Franklin Watkins and Ott, {Brian R.} and Geoffrey Tremont and Daiello, {Lori A.} and Stephen Salloway and Paul Malloy and Stephen Correia and Rosen, {Howard J.} and Miller, {Bruce L.} and David Perry and Jacobo Mintzer and Kenneth Spicer and David Bachman and Nunzio Pomara and Raymundo Hernando and Antero Sarrael and Schultz, {Susan K.} and {Ekstam Smith}, Karen and Hristina Koleva and Nam, {Ki Won} and Hyungsub Shim and Norman Relkin and Gloria Chaing and Michael Lin and Lisa Ravdin and Amanda Smith and {Ashok Raj}, Balebail and Kristin Fargher",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41598-017-13930-y",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

AU - Du, Lei

AU - Liu, Kefei

AU - Yao, Xiaohui

AU - Yan, Jingwen

AU - Risacher, Shannon L.

AU - Han, Junwei

AU - Guo, Lei

AU - Saykin, Andrew J.

AU - Shen, Li

AU - Weiner, Michael W.

AU - Aisen, Paul

AU - Petersen, Ronald

AU - Jack, Clifford R.

AU - Jagust, William

AU - Trojanowki, John Q.

AU - Toga, Arthur W.

AU - Beckett, Laurel

AU - Green, Robert C.

AU - Morris, John

AU - Shaw, Leslie M.

AU - Khachaturian, Zaven

AU - Sorensen, Greg

AU - Carrillo, Maria

AU - Kuller, Lew

AU - Raichle, Marc

AU - Paul, Steven

AU - Davies, Peter

AU - Fillit, Howard

AU - Hefti, Franz

AU - Holtzman, David

AU - Mesulam, M. Marcel

AU - Potter, William

AU - Snyder, Peter

AU - Schwartz, Adam

AU - Montine, Tom

AU - Thomas, Ronald G.

AU - Donohue, Michael

AU - Walter, Sarah

AU - Gessert, Devon

AU - Sather, Tamie

AU - Jiminez, Gus

AU - Balasubramanian, Archana B.

AU - Mason, Jennifer

AU - Sim, Iris

AU - Harvey, Danielle

AU - Bernstein, Matthew

AU - Fox, Nick

AU - Thompson, Paul

AU - Schuff, Norbert

AU - Decarli, Charles

AU - Borowski, Bret

AU - Gunter, Jeff

AU - Senjem, Matt

AU - Vemuri, Prashanthi

AU - Jones, David

AU - Kantarci, Kejal

AU - Ward, Chad

AU - Koeppe, Robert A.

AU - Foster, Norm

AU - Reiman, Eric M.

AU - Chen, Kewei

AU - Mathis, Chet

AU - Landau, Susan

AU - Cairns, Nigel J.

AU - Franklin, Erin

AU - Taylor-Reinwald, Lisa

AU - Lee, Virginia

AU - Korecka, Magdalena

AU - Figurski, Michal

AU - Crawford, Karen

AU - Neu, Scott

AU - Foroud, Tatiana M.

AU - Potkin, Steven

AU - Faber, Kelley

AU - Kim, Sungeun

AU - Nho, Kwangsik

AU - Thal, Leon

AU - Buckholtz, Neil

AU - Albert, Marilyn

AU - Frank, Richard

AU - Hsiao, John

AU - Kaye, Jeffrey

AU - Quinn, Joseph

AU - Silbert, Lisa

AU - Lind, Betty

AU - Carter, Raina

AU - Dolen, Sara

AU - Schneider, Lon S.

AU - Pawluczyk, Sonia

AU - Beccera, Mauricio

AU - Teodoro, Liberty

AU - Spann, Bryan M.

AU - Brewer, James

AU - Vanderswag, Helen

AU - Fleisher, Adam

AU - Heidebrink, Judith L.

AU - Lord, Joanne L.

AU - Mason, Sara S.

AU - Albers, Colleen S.

AU - Knopman, David

AU - Johnson, Kris

AU - Doody, Rachelle S.

AU - Villanueva-Meyer, Javier

AU - Pavlik, Valory

AU - Shibley, Victoria

AU - Chowdhury, Munir

AU - Rountree, Susan

AU - Dang, Mimi

AU - Stern, Yaakov

AU - Honig, Lawrence S.

AU - Bell, Karen L.

AU - Ances, Beau

AU - Carroll, Maria

AU - Creech, Mary L.

AU - Franklin, Erin

AU - Mintun, Mark A.

AU - Schneider, Stacy

AU - Oliver, Angela

AU - Marson, Daniel

AU - Geldmacher, David

AU - Love, Marissa Natelson

AU - Griffith, Randall

AU - Clark, David

AU - Brockington, John

AU - Roberson, Erik

AU - Grossman, Hillel

AU - Mitsis, Effie

AU - Shah, Raj C.

AU - Detoledo-Morrell, Leyla

AU - Duara, Ranjan

AU - Greig-Custo, Maria T.

AU - Barker, Warren

AU - Onyike, Chiadi

AU - D'Agostino, Daniel

AU - Kielb, Stephanie

AU - Sadowski, Martin

AU - Sheikh, Mohammed O.

AU - Ulysse, Anaztasia

AU - Gaikwad, Mrunalini

AU - Murali Doraiswamy, P.

AU - Petrella, Jeffrey R.

AU - Borges-Neto, Salvador

AU - Wong, Terence Z.

AU - Coleman, Edward

AU - Arnold, Steven E.

AU - Karlawish, Jason H.

AU - Wolk, David A.

AU - Clark, Christopher M.

AU - Smith, Charles D.

AU - Jicha, Greg

AU - Hardy, Peter

AU - Sinha, Partha

AU - Oates, Elizabeth

AU - Conrad, Gary

AU - Lopez, Oscar L.

AU - Oakley, Mary Ann

AU - Simpson, Donna M.

AU - Porsteinsson, Anton P.

AU - Goldstein, Bonnie S.

AU - Martin, Kim

AU - Makino, Kelly M.

AU - Ismail, M. Saleem

AU - Brand, Connie

AU - Preda, Adrian

AU - Nguyen, Dana

AU - Womack, Kyle

AU - Mathews, Dana

AU - Quiceno, Mary

AU - Levey, Allan I.

AU - Lah, James J.

AU - Cellar, Janet S.

AU - Burns, Jeffrey M.

AU - Swerdlow, Russell H.

AU - Brooks, William M.

AU - Apostolova, Liana

AU - Tingus, Kathleen

AU - Woo, Ellen

AU - Silverman, Daniel H.S.

AU - Lu, Po H.

AU - Bartzokis, George

AU - Graff-Radford, Neill R.

AU - Parfitt, Francine

AU - Poki-Walker, Kim

AU - Farlow, Martin R.

AU - Marie Hake, Ann

AU - Matthews, Brandy R.

AU - Brosch, Jared R.

AU - Herring, Scott

AU - Van Dyck, Christopher H.

AU - Carson, Richard E.

AU - MacAvoy, Martha G.

AU - Varma, Pradeep

AU - Chertkow, Howard

AU - Bergman, Howard

AU - Hosein, Chris

AU - Black, Sandra

AU - Stefanovic, Bojana

AU - Caldwell, Curtis

AU - Robin Hsiung, Ging Yuek

AU - Mudge, Benita

AU - Sossi, Vesna

AU - Feldman, Howard

AU - Assaly, Michele

AU - Finger, Elizabeth

AU - Pasternack, Stephen

AU - Rachisky, Irina

AU - Rogers, John

AU - Trost, Dick

AU - Kertesz, Andrew

AU - Bernick, Charles

AU - Munic, Donna

AU - Rogalski, Emily

AU - Lipowski, Kristine

AU - Weintraub, Sandra

AU - Bonakdarpour, Borna

AU - Kerwin, Diana

AU - Wu, Chuang Kuo

AU - Johnson, Nancy

AU - Sadowsky, Carl

AU - Villena, Teresa

AU - Scott Turner, Raymond

AU - Johnson, Kathleen

AU - Reynolds, Brigid

AU - Sperling, Reisa A.

AU - Johnson, Keith A.

AU - Marshall, Gad

AU - Yesavage, Jerome

AU - Taylor, Joy L.

AU - Lane, Barton

AU - Rosen, Allyson

AU - Tinklenberg, Jared

AU - Sabbagh, Marwan N.

AU - Belden, Christine M.

AU - Jacobson, Sandra A.

AU - Sirrel, Sherye A.

AU - Kowall, Neil

AU - Killiany, Ronald

AU - Budson, Andrew E.

AU - Norbash, Alexander

AU - Lynn Johnson, Patricia

AU - Obisesan, Thomas O.

AU - Wolday, Saba

AU - Allard, Joanne

AU - Lerner, Alan

AU - Ogrocki, Paula

AU - Tatsuoka, Curtis

AU - Fatica, Parianne

AU - Fletcher, Evan

AU - Maillard, Pauline

AU - Olichney, John

AU - Decarli, Charles

AU - Carmichael, Owen

AU - Kittur, Smita

AU - Borrie, Michael

AU - Lee, T. Y.

AU - Bartha, Rob

AU - Johnson, Sterling

AU - Asthana, Sanjay

AU - Carlsson, Cynthia M.

AU - Tariot, Pierre

AU - Burke, Anna

AU - Milliken, Ann Marie

AU - Trncic, Nadira

AU - Fleisher, Adam

AU - Reeder, Stephanie

AU - Bates, Vernice

AU - Capote, Horacio

AU - Rainka, Michelle

AU - Scharre, Douglas W.

AU - Kataki, Maria

AU - Kelly, Brendan

AU - Zimmerman, Earl A.

AU - Celmins, Dzintra

AU - Brown, Alice D.

AU - Pearlson, Godfrey D.

AU - Blank, Karen

AU - Anderson, Karen

AU - Flashman, Laura A.

AU - Seltzer, Marc

AU - Hynes, Mary L.

AU - Santulli, Robert B.

AU - Sink, Kaycee M.

AU - Gordineer, Leslie

AU - Williamson, Jeff D.

AU - Garg, Pradeep

AU - Watkins, Franklin

AU - Ott, Brian R.

AU - Tremont, Geoffrey

AU - Daiello, Lori A.

AU - Salloway, Stephen

AU - Malloy, Paul

AU - Correia, Stephen

AU - Rosen, Howard J.

AU - Miller, Bruce L.

AU - Perry, David

AU - Mintzer, Jacobo

AU - Spicer, Kenneth

AU - Bachman, David

AU - Pomara, Nunzio

AU - Hernando, Raymundo

AU - Sarrael, Antero

AU - Schultz, Susan K.

AU - Ekstam Smith, Karen

AU - Koleva, Hristina

AU - Nam, Ki Won

AU - Shim, Hyungsub

AU - Relkin, Norman

AU - Chaing, Gloria

AU - Lin, Michael

AU - Ravdin, Lisa

AU - Smith, Amanda

AU - Ashok Raj, Balebail

AU - Fargher, Kristin

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only convex, but also singular at the origin, which is a necessary condition for sparsity. Thus most SCCA methods impose ℓ 1 -norm onto the individual feature or the structure level of features to pursuit corresponding sparsity. However, the ℓ1 -norm penalty over-penalizes large coefficients and may incurs estimation bias. A number of non-convex penalties are proposed to reduce the estimation bias in regression tasks. But using them in SCCA remains largely unexplored. In this paper, we design a unified non-convex SCCA model, based on seven non-convex functions, for unbiased estimation and stable feature selection simultaneously. We also propose an efficient optimization algorithm. The proposed method obtains both higher correlation coefficients and better canonical loading patterns. Specifically, these SCCA methods with non-convex penalties discover a strong association between the APOE e4 rs429358 SNP and the hippocampus region of the brain. They both are Alzheimer's disease related biomarkers, indicating the potential and power of the non-convex methods in brain imaging genetics.

AB - Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only convex, but also singular at the origin, which is a necessary condition for sparsity. Thus most SCCA methods impose ℓ 1 -norm onto the individual feature or the structure level of features to pursuit corresponding sparsity. However, the ℓ1 -norm penalty over-penalizes large coefficients and may incurs estimation bias. A number of non-convex penalties are proposed to reduce the estimation bias in regression tasks. But using them in SCCA remains largely unexplored. In this paper, we design a unified non-convex SCCA model, based on seven non-convex functions, for unbiased estimation and stable feature selection simultaneously. We also propose an efficient optimization algorithm. The proposed method obtains both higher correlation coefficients and better canonical loading patterns. Specifically, these SCCA methods with non-convex penalties discover a strong association between the APOE e4 rs429358 SNP and the hippocampus region of the brain. They both are Alzheimer's disease related biomarkers, indicating the potential and power of the non-convex methods in brain imaging genetics.

UR - http://www.scopus.com/inward/record.url?scp=85032193550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032193550&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-13930-y

DO - 10.1038/s41598-017-13930-y

M3 - Article

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 14052

ER -