Patterns of involvement with malignant lymphoma and implications for treatment decision making

R. E. Johnson, V. T. DeVita, L. E. Kun, B. R. Chabner, P. B. Chretien, C. W. Berard, S. K. Johnson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Decision making in cancer therapy has traditionally evolved through careful observation of the clinical course subsequent to various treatment approaches. This method has also served to delineate the wide spectrum of primary manifestations and patterns of biological behavior characterizing the malignant lymphomata. Marked disparity has been consistently appreciated between the natural history of lymphomata originating in lymph nodes in contrast to those primary in extranodal sites. The former are usually anatomically generalized at diagnosis whereas primary extranodal lymphomata are commonly localized and more closely resemble carcinomata of the respective organs with their propensity for both regional lymphatic extension and hematogenous spread. Prospective staging of 100 consecutive patients with previously untreated malignant lymphoma has been consistent with this past experience in demonstrating the presence of disseminated invovement in the majority of patients. It has also become apparent that reliance upon either clinical or surgical staging of disease extent is often misleading since widespread disease frequently develops even in those patients staged as having localized involvement and thereby treated with local irradiation. High dose, wide field lymphatic irradiation 'a la Hodgkins disease' seldom constitutes appropriate treatment for patients having lymph node presentations of lymphoma. There is rather a need to recognize the importance of systemic treatment for most cases, negating the utility of routine exhaustive staging since treatment decisions can be based upon readily assessed clinicohistologic determinants in the majority of cases.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalBritish Journal of Cancer
Volume31
Issue numberSupII
StatePublished - Dec 1 1975

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Lymphoma
Decision Making
Lymph Nodes
Lymphatic Irradiation
Therapeutics
Hodgkin Disease
Observation
Carcinoma
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Johnson, R. E., DeVita, V. T., Kun, L. E., Chabner, B. R., Chretien, P. B., Berard, C. W., & Johnson, S. K. (1975). Patterns of involvement with malignant lymphoma and implications for treatment decision making. British Journal of Cancer, 31(SupII), 237-241.

Patterns of involvement with malignant lymphoma and implications for treatment decision making. / Johnson, R. E.; DeVita, V. T.; Kun, L. E.; Chabner, B. R.; Chretien, P. B.; Berard, C. W.; Johnson, S. K.

In: British Journal of Cancer, Vol. 31, No. SupII, 01.12.1975, p. 237-241.

Research output: Contribution to journalArticle

Johnson, RE, DeVita, VT, Kun, LE, Chabner, BR, Chretien, PB, Berard, CW & Johnson, SK 1975, 'Patterns of involvement with malignant lymphoma and implications for treatment decision making', British Journal of Cancer, vol. 31, no. SupII, pp. 237-241.
Johnson RE, DeVita VT, Kun LE, Chabner BR, Chretien PB, Berard CW et al. Patterns of involvement with malignant lymphoma and implications for treatment decision making. British Journal of Cancer. 1975 Dec 1;31(SupII):237-241.
Johnson, R. E. ; DeVita, V. T. ; Kun, L. E. ; Chabner, B. R. ; Chretien, P. B. ; Berard, C. W. ; Johnson, S. K. / Patterns of involvement with malignant lymphoma and implications for treatment decision making. In: British Journal of Cancer. 1975 ; Vol. 31, No. SupII. pp. 237-241.
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