Penile hemodynamics in hypogonadal men with micropenis

Pinar Kad̀ioǧlu, Ahmet Tefekli, Bülent Erol, Öner Şanli, Muammer Kendirci, Eşref Özer, Üstün Korugan, Ateş Kadioǧlu

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Abstract

Objectives. To document the penile vascular and erectile response to intracavernous injection (ICI) of vasoactive agent in hypogonadal men with micropenis. Methods. A total of 15, previously untreated, hypogonadal men with micropenis (stretched penis length less than 2.5 SD below the mean of the normal population) underwent a detailed urologic and endocrinologic evaluation. Their mean age was 21.2 ± 4.2 years. Penile hemodynamics were assessed by color Doppler ultrasonography before and after ICI of 5 μg of prostaglandin E1 combined with manual genital self-stimulation. Results. Endocrinologic evaluation revealed that hypogonadism was hypogonadotropic in 10 (66.7%) and hypergonadotropic in 5 (33.3%). Karyotype analysis showed 46XY in all. Their mean stretched penile length was 6.2 ± 1.4 cm (range 3 to 7.5) and increased to a mean of 6.96 ± 1.5 cm (range 4 to 8.5) after ICI. The serum free testosterone levels ranged from 0.2 to 3.2 pg/mL (mean 1.9 ± 0.92). None had had any previous sexual experience, and 14 (93.3%) reported a history of nocturnal erections. Penile color Doppler ultrasonography demonstrated a normal penile vascular system in 7 (46.7%) and penile arterial insufficiency in 4 (28.6%). All 11 of these patients (73.3%) achieved an adequate erectile response to ICI combined with manual stimulation. Mixed vascular disease was observed in the remaining 4 patients (28.8%), and they did not have a sufficient erectile response to ICI. Color Doppler ultrasonography revealed similar results in the hypogonadotropic and hypergonadotropic men. Conclusions. Our data suggest that the erectile response to ICI combined with manual genital self-stimulation is effective in most hypogonadal men having a micropenis with low serum androgen levels.

Original languageEnglish (US)
Pages (from-to)426-430
Number of pages5
JournalUrology
Volume61
Issue number2
DOIs
StatePublished - Feb 1 2003

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Hemodynamics
Doppler Color Ultrasonography
Injections
Self Stimulation
Blood Vessels
Hypogonadism
Alprostadil
Penis
Serum
Karyotype
Vascular Diseases
Androgens
Testosterone
Penis agenesis
Population

ASJC Scopus subject areas

  • Urology

Cite this

Kad̀ioǧlu, P., Tefekli, A., Erol, B., Şanli, Ö., Kendirci, M., Özer, E., ... Kadioǧlu, A. (2003). Penile hemodynamics in hypogonadal men with micropenis. Urology, 61(2), 426-430. https://doi.org/10.1016/S0090-4295(02)02262-8

Penile hemodynamics in hypogonadal men with micropenis. / Kad̀ioǧlu, Pinar; Tefekli, Ahmet; Erol, Bülent; Şanli, Öner; Kendirci, Muammer; Özer, Eşref; Korugan, Üstün; Kadioǧlu, Ateş.

In: Urology, Vol. 61, No. 2, 01.02.2003, p. 426-430.

Research output: Contribution to journalArticle

Kad̀ioǧlu, P, Tefekli, A, Erol, B, Şanli, Ö, Kendirci, M, Özer, E, Korugan, Ü & Kadioǧlu, A 2003, 'Penile hemodynamics in hypogonadal men with micropenis', Urology, vol. 61, no. 2, pp. 426-430. https://doi.org/10.1016/S0090-4295(02)02262-8
Kad̀ioǧlu P, Tefekli A, Erol B, Şanli Ö, Kendirci M, Özer E et al. Penile hemodynamics in hypogonadal men with micropenis. Urology. 2003 Feb 1;61(2):426-430. https://doi.org/10.1016/S0090-4295(02)02262-8
Kad̀ioǧlu, Pinar ; Tefekli, Ahmet ; Erol, Bülent ; Şanli, Öner ; Kendirci, Muammer ; Özer, Eşref ; Korugan, Üstün ; Kadioǧlu, Ateş. / Penile hemodynamics in hypogonadal men with micropenis. In: Urology. 2003 ; Vol. 61, No. 2. pp. 426-430.
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abstract = "Objectives. To document the penile vascular and erectile response to intracavernous injection (ICI) of vasoactive agent in hypogonadal men with micropenis. Methods. A total of 15, previously untreated, hypogonadal men with micropenis (stretched penis length less than 2.5 SD below the mean of the normal population) underwent a detailed urologic and endocrinologic evaluation. Their mean age was 21.2 ± 4.2 years. Penile hemodynamics were assessed by color Doppler ultrasonography before and after ICI of 5 μg of prostaglandin E1 combined with manual genital self-stimulation. Results. Endocrinologic evaluation revealed that hypogonadism was hypogonadotropic in 10 (66.7{\%}) and hypergonadotropic in 5 (33.3{\%}). Karyotype analysis showed 46XY in all. Their mean stretched penile length was 6.2 ± 1.4 cm (range 3 to 7.5) and increased to a mean of 6.96 ± 1.5 cm (range 4 to 8.5) after ICI. The serum free testosterone levels ranged from 0.2 to 3.2 pg/mL (mean 1.9 ± 0.92). None had had any previous sexual experience, and 14 (93.3{\%}) reported a history of nocturnal erections. Penile color Doppler ultrasonography demonstrated a normal penile vascular system in 7 (46.7{\%}) and penile arterial insufficiency in 4 (28.6{\%}). All 11 of these patients (73.3{\%}) achieved an adequate erectile response to ICI combined with manual stimulation. Mixed vascular disease was observed in the remaining 4 patients (28.8{\%}), and they did not have a sufficient erectile response to ICI. Color Doppler ultrasonography revealed similar results in the hypogonadotropic and hypergonadotropic men. Conclusions. Our data suggest that the erectile response to ICI combined with manual genital self-stimulation is effective in most hypogonadal men having a micropenis with low serum androgen levels.",
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AU - Tefekli, Ahmet

AU - Erol, Bülent

AU - Şanli, Öner

AU - Kendirci, Muammer

AU - Özer, Eşref

AU - Korugan, Üstün

AU - Kadioǧlu, Ateş

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AB - Objectives. To document the penile vascular and erectile response to intracavernous injection (ICI) of vasoactive agent in hypogonadal men with micropenis. Methods. A total of 15, previously untreated, hypogonadal men with micropenis (stretched penis length less than 2.5 SD below the mean of the normal population) underwent a detailed urologic and endocrinologic evaluation. Their mean age was 21.2 ± 4.2 years. Penile hemodynamics were assessed by color Doppler ultrasonography before and after ICI of 5 μg of prostaglandin E1 combined with manual genital self-stimulation. Results. Endocrinologic evaluation revealed that hypogonadism was hypogonadotropic in 10 (66.7%) and hypergonadotropic in 5 (33.3%). Karyotype analysis showed 46XY in all. Their mean stretched penile length was 6.2 ± 1.4 cm (range 3 to 7.5) and increased to a mean of 6.96 ± 1.5 cm (range 4 to 8.5) after ICI. The serum free testosterone levels ranged from 0.2 to 3.2 pg/mL (mean 1.9 ± 0.92). None had had any previous sexual experience, and 14 (93.3%) reported a history of nocturnal erections. Penile color Doppler ultrasonography demonstrated a normal penile vascular system in 7 (46.7%) and penile arterial insufficiency in 4 (28.6%). All 11 of these patients (73.3%) achieved an adequate erectile response to ICI combined with manual stimulation. Mixed vascular disease was observed in the remaining 4 patients (28.8%), and they did not have a sufficient erectile response to ICI. Color Doppler ultrasonography revealed similar results in the hypogonadotropic and hypergonadotropic men. Conclusions. Our data suggest that the erectile response to ICI combined with manual genital self-stimulation is effective in most hypogonadal men having a micropenis with low serum androgen levels.

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