Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics

Sourav S. Patnaik, Dan T. Simionescu, Craig J. Goergen, Kenneth Hoyt, Shashank Sirsi, Ender A. Finol

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Pentagalloyl glucose (PGG) is an elastin-stabilizing polyphenolic compound that has significant biomedical benefits, such as being a free radical sink, an anti-inflammatory agent, anti-diabetic agent, enzymatic resistant properties, etc. This review article focuses on the important benefits of PGG on vascular health, including its role in tissue mechanics, the different modes of pharmacological administration (e.g., oral, intravenous and endovascular route, intraperitoneal route, subcutaneous route, and nanoparticle based delivery and microbubble-based delivery), and its potential therapeutic role in vascular diseases such as abdominal aortic aneurysms (AAA). In particular, the use of PGG for AAA suppression and prevention has been demonstrated to be effective only in the calcium chloride rat AAA model. Therefore, in this critical review we address the challenges that lie ahead for the clinical translation of PGG as an AAA growth suppressor.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Abdominal aortic aneurysms
  • Collagen
  • Drug delivery
  • Elastin
  • Pentagalloyl glucose

ASJC Scopus subject areas

  • Biomedical Engineering

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