Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit

Weike Tao, Joseph B. Zwischenberger, Thuan T. Nguyen, Alexander E. Tzouanakis, Edward J. Matheis, Daniel L. Traber, Akhil Bidani

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To analyze quantitatively the performance of the intravenacaval blood gas exchanger (IVOX), we developed a right atrium-pulmonary artery venovenous extracorporeal bypass circuit Oxygen transfer and carbon dioxide removal were calculated at different blood flow rates, different hemoglobin levels, and during permissive hypercapnia. Oxygen transfer increased linearly with blood flow up to 41 mL/min. Likewise, O2 transfer increased linearly with hemoglobin levels up to 7. 5 g/dL, but no further increases were achieved above this level. Carbon dioxide removal increased linearly as flow increased from 1.0 to 3.0 L/min but did not increase further for higher flows. Carbon dioxide removal was 45 mL/min at blood carbon dioxide tension of 42 mm Hg but increased to a maximum of 81 mL/min at a carbon dioxide tension of 90 mm Hg. We conclude that IVOX is a diffusion-limited device dependent on blood flow, hemoglobin content, and the gas pressure gradient across the membrane. Further engineering improvements are needed to improve the gas exchange performance of IVOX.

Original languageEnglish (US)
Pages (from-to)1484-1491
Number of pages8
JournalThe Annals of Thoracic Surgery
Volume57
Issue number6
StatePublished - Jun 1994

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Carbon Dioxide
Gases
Hemoglobins
Oxygen
Hypercapnia
Heart Atria
Pulmonary Artery
Pressure
Equipment and Supplies
Membranes

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Tao, W., Zwischenberger, J. B., Nguyen, T. T., Tzouanakis, A. E., Matheis, E. J., Traber, D. L., & Bidani, A. (1994). Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit. The Annals of Thoracic Surgery, 57(6), 1484-1491.

Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit. / Tao, Weike; Zwischenberger, Joseph B.; Nguyen, Thuan T.; Tzouanakis, Alexander E.; Matheis, Edward J.; Traber, Daniel L.; Bidani, Akhil.

In: The Annals of Thoracic Surgery, Vol. 57, No. 6, 06.1994, p. 1484-1491.

Research output: Contribution to journalArticle

Tao, W, Zwischenberger, JB, Nguyen, TT, Tzouanakis, AE, Matheis, EJ, Traber, DL & Bidani, A 1994, 'Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit', The Annals of Thoracic Surgery, vol. 57, no. 6, pp. 1484-1491.
Tao W, Zwischenberger JB, Nguyen TT, Tzouanakis AE, Matheis EJ, Traber DL et al. Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit. The Annals of Thoracic Surgery. 1994 Jun;57(6):1484-1491.
Tao, Weike ; Zwischenberger, Joseph B. ; Nguyen, Thuan T. ; Tzouanakis, Alexander E. ; Matheis, Edward J. ; Traber, Daniel L. ; Bidani, Akhil. / Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit. In: The Annals of Thoracic Surgery. 1994 ; Vol. 57, No. 6. pp. 1484-1491.
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