Perinatal Factors Associated with Autism Spectrum Disorder in Jamaican Children

Sepideh Saroukhani, Maureen Samms-Vaughan, Min Jae Lee, MacKinsey K.A. Bach, Jan Bressler, Manouchehr Hessabi, Megan L. Grove, Sydonnie Shakespeare-Pellington, Katherine A. Loveland, Mohammad H. Rahbar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Mode of delivery, preterm birth, and low birth weight (LBW) are hypothesized to be associated with autism spectrum disorder (ASD) in the offspring. Using data from 343 ASD cases (2–8 years) and their age- and sex-matched typically developing controls in Jamaica we investigated these hypotheses. Our statistical analyses revealed that the parish of residence could modify the association between cesarean delivery and ASD, with a difference found in this relationship in Kingston parish [matched odds ratio (MOR) (95% confidence interval (CI)) 2.30 (1.17–4.53)] and other parishes [MOR (95% CI) 0.87 (0.48–1.59)]. Although the associations of LBW and preterm birth with ASD were not significant, we observed a significant interaction between LBW and the household socioeconomic status. These findings require replication.

Original languageEnglish (US)
Pages (from-to)3341-3357
Number of pages17
JournalJournal of Autism and Developmental Disorders
Volume50
Issue number9
DOIs
StatePublished - Sep 1 2020
Externally publishedYes

Keywords

  • Autism spectrum disorder
  • Cesarean delivery
  • Jamaica
  • Low birth weight
  • Preterm birth

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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