TY - JOUR
T1 - Perinatal Factors Associated with Autism Spectrum Disorder in Jamaican Children
AU - Saroukhani, Sepideh
AU - Samms-Vaughan, Maureen
AU - Lee, Min Jae
AU - Bach, MacKinsey K.A.
AU - Bressler, Jan
AU - Hessabi, Manouchehr
AU - Grove, Megan L.
AU - Shakespeare-Pellington, Sydonnie
AU - Loveland, Katherine A.
AU - Rahbar, Mohammad H.
N1 - Funding Information:
This research is co-funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health Fogarty International Center (NIH-FIC) by a grant (R21HD057808; PI: Rahbar), as well as by a grant (R01ES022165; PI: Rahbar) from the National Institute of Environmental Health Sciences (NIEHS) awarded to The University of Texas Health Science Center at Houston. We also acknowledge the support provided by the Biostatistics/Epidemiology/Research Design (BERD) component of the Center for Clinical and Translational Sciences (CCTS) for this project. CCTS is mainly funded by the NIH Centers for Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to The University of Texas Health Science Center at Houston in 2006 by the National Center for Research Resources (NCRR) and its renewal (UL1TR000371) by the National Center for Advancing Translational Sciences (NCATS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NICHD or the NIH-FIC or NIEHS or the NCRR or the NCATS.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Mode of delivery, preterm birth, and low birth weight (LBW) are hypothesized to be associated with autism spectrum disorder (ASD) in the offspring. Using data from 343 ASD cases (2–8 years) and their age- and sex-matched typically developing controls in Jamaica we investigated these hypotheses. Our statistical analyses revealed that the parish of residence could modify the association between cesarean delivery and ASD, with a difference found in this relationship in Kingston parish [matched odds ratio (MOR) (95% confidence interval (CI)) 2.30 (1.17–4.53)] and other parishes [MOR (95% CI) 0.87 (0.48–1.59)]. Although the associations of LBW and preterm birth with ASD were not significant, we observed a significant interaction between LBW and the household socioeconomic status. These findings require replication.
AB - Mode of delivery, preterm birth, and low birth weight (LBW) are hypothesized to be associated with autism spectrum disorder (ASD) in the offspring. Using data from 343 ASD cases (2–8 years) and their age- and sex-matched typically developing controls in Jamaica we investigated these hypotheses. Our statistical analyses revealed that the parish of residence could modify the association between cesarean delivery and ASD, with a difference found in this relationship in Kingston parish [matched odds ratio (MOR) (95% confidence interval (CI)) 2.30 (1.17–4.53)] and other parishes [MOR (95% CI) 0.87 (0.48–1.59)]. Although the associations of LBW and preterm birth with ASD were not significant, we observed a significant interaction between LBW and the household socioeconomic status. These findings require replication.
KW - Autism spectrum disorder
KW - Cesarean delivery
KW - Jamaica
KW - Low birth weight
KW - Preterm birth
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U2 - 10.1007/s10803-019-04229-0
DO - 10.1007/s10803-019-04229-0
M3 - Article
C2 - 31538260
AN - SCOPUS:85073951856
VL - 50
SP - 3341
EP - 3357
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 9
ER -