Periodicity, repression, and the molecular architecture of the mammalian circadian clock

Clark Rosensweig, Carla B Green

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Large molecular machines regulate daily cycles of transcriptional activity and help generate rhythmic behavior. In recent years, structural and biochemical analyses have elucidated a number of principles guiding the interactions of proteins that form the basis of circadian timing. In its simplest form, the circadian clock is composed of a transcription/translation feedback loop. However, this description elides a complicated process of activator recruitment, chromatin decompaction, recruitment of coactivators, expression of repressors, formation of a repressive complex, repression of the activators, and ultimately degradation of the repressors and reinitiation of the cycle. Understanding the core principles underlying the clock requires careful examination of molecular and even atomic level details of these processes. Here, we review major structural and biochemical findings in circadian biology and make the argument that shared protein interfaces within the clockwork are critical for both the generation of rhythmicity and timing of the clock.

Original languageEnglish (US)
JournalEuropean Journal of Neuroscience
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Circadian Clocks
Periodicity
Activity Cycles
Chromatin
Proteins

Keywords

  • clock
  • cryptochrome
  • period
  • rhythm
  • transcription

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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