Perioperative care in an adolescent patient with heparin-induced thrombocytopenia for placement of a cardiac assist device and heart transplantation: Case report and literature review

Mineto Kamata, Roby Sebastian, Patrick I. McConnell, Daniel Gomez, Aymen Naguib, Joseph D. Tobias

Research output: Contribution to journalReview article

4 Scopus citations


Heparin-induced thrombocytopenia (HIT) can cause life-threatening complications following the administration of heparin. Discontinuation of all sources of heparin exposure and the use of alternative agents for anticoagulation are necessary when HIT is suspected or diagnosed. We present the successful use of bivalirudin anticoagulation in an adolescent patient during cardiopulmonary bypass who underwent both placement of a left ventricular assist device and subsequent heart transplantation within a 36-hour period. The pathophysiology and diagnosis of HIT are reviewed, previous reports of the use of direct thrombin inhibitors for cardiac surgery are presented, and potential dosing regimens for bivalirudin are discussed.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalInternational Medical Case Reports Journal
StatePublished - Feb 14 2017



  • Anticoagulation
  • Bivalirudin
  • Cardiopulmonary bypass
  • Heart transplant

ASJC Scopus subject areas

  • Medicine(all)

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