TY - JOUR
T1 - Peripheral arterial disease
T2 - A manifestation of evolutionary dislocation and feed-forward dysfunction
AU - Simpson, John D.
AU - Doux, John D.
AU - Lee, Patrick Y.
AU - Yun, Anthony J.
PY - 2006
Y1 - 2006
N2 - Peripheral arterial disease in the legs represents a subset of atherosclerosis that manifests a particularly sinister profile. A predominance of sympathetic activity in the periphery favors the development of neurogenic atherosclerosis. Atherosclerosis may then produce flow derangements and decreased physical activity that serves to escalate sympathetic bias in a vicious cycle. Restoration of normal flow in peripheral arterial disease may not only produce local benefit due to improved perfusion, but also represent a gateway to correcting many systemic conditions that may at first glance appear unrelated but share a common etiology of autonomic dysfunction, such as gout, acute coronary syndromes, stroke, sleep apnea, arrhythmias, depression, erectile dysfunction, inflammation, hypercoagulability, sleep disorders, bowel dysfunction, renal failure, and aging.
AB - Peripheral arterial disease in the legs represents a subset of atherosclerosis that manifests a particularly sinister profile. A predominance of sympathetic activity in the periphery favors the development of neurogenic atherosclerosis. Atherosclerosis may then produce flow derangements and decreased physical activity that serves to escalate sympathetic bias in a vicious cycle. Restoration of normal flow in peripheral arterial disease may not only produce local benefit due to improved perfusion, but also represent a gateway to correcting many systemic conditions that may at first glance appear unrelated but share a common etiology of autonomic dysfunction, such as gout, acute coronary syndromes, stroke, sleep apnea, arrhythmias, depression, erectile dysfunction, inflammation, hypercoagulability, sleep disorders, bowel dysfunction, renal failure, and aging.
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U2 - 10.1016/j.mehy.2006.03.027
DO - 10.1016/j.mehy.2006.03.027
M3 - Article
C2 - 16701960
AN - SCOPUS:33745951872
SN - 0306-9877
VL - 67
SP - 947
EP - 950
JO - Medical Hypotheses
JF - Medical Hypotheses
IS - 4
ER -