Peripheral arterial disease: A manifestation of evolutionary dislocation and feed-forward dysfunction

John D. Simpson, John D. Doux, Patrick Y. Lee, Anthony J. Yun

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Peripheral arterial disease in the legs represents a subset of atherosclerosis that manifests a particularly sinister profile. A predominance of sympathetic activity in the periphery favors the development of neurogenic atherosclerosis. Atherosclerosis may then produce flow derangements and decreased physical activity that serves to escalate sympathetic bias in a vicious cycle. Restoration of normal flow in peripheral arterial disease may not only produce local benefit due to improved perfusion, but also represent a gateway to correcting many systemic conditions that may at first glance appear unrelated but share a common etiology of autonomic dysfunction, such as gout, acute coronary syndromes, stroke, sleep apnea, arrhythmias, depression, erectile dysfunction, inflammation, hypercoagulability, sleep disorders, bowel dysfunction, renal failure, and aging.

Original languageEnglish (US)
Pages (from-to)947-950
Number of pages4
JournalMedical Hypotheses
Issue number4
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Peripheral arterial disease: A manifestation of evolutionary dislocation and feed-forward dysfunction'. Together they form a unique fingerprint.

Cite this