Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis

K. Sato, S. Shelton, J. D. Nelson

Research output: Contribution to journalArticle

Abstract

Rabbits with experimentally induced pneumococcal meningitis were given single 25-mg/kg doses of apalcillin or cefpiramide. Mean percentages of the drug concentration in cerebrospinal fluid versus that in blood serum were 7.6% with apalcillin and 3.9% with cefpiramide. Bactericidal activity in cerebrospinal fluid resulted in mean reductions of from 4 to 5 log10 CFU/ml, and cerebrospinal fluid cultures became sterile for 4 of 6 animals treated with each drug.

Original languageEnglish (US)
Pages (from-to)578-579
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume26
Issue number4
DOIs
StatePublished - Jan 1 1984

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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