Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation

Steve N. Caritis, Shringi Sharma, Raman Venkataramanan, Dwight J. Rouse, Alan M. Peaceman, Anthony Sciscione, Catherine Y. Spong, Michael W. Varner, Fergal D. Malone, Jay D. Iams, Brian M. Mercer, John M. Thorp, Yoram Sorokin, Marshall Carpenter, Julie Lo, Susan Ramin, Margaret Harper

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: The purpose of this study was to define the pharmacokinetic parameters of 17-hydroxyprogesterone caproate (17-OHPC) in multifetal gestation. Study Design: Blood was obtained at 24-28 weeks' gestation and at 3235 weeks gestation in 97 women with twin and 26 women with triplet gestation who were receiving 17-OHPC. Six of the women with twins had daily blood sampling for 7 days between 24 and 28 weeks' gestation, and pharmacokinetic parameters were estimated with the use of noncompartmental analysis. Modeling was applied to estimate the population parameters and to simulate various treatment scenarios. Results: The apparent half-life of 17-OHPC was 10 days. Body mass index significantly impacted 17-OHPC concentrations, but fetal number and parity did not. Apparent clearance was significantly greater in African American than in white women (P = .025). Conclusion: This is the first pharmacokinetic analysis of 17-OHPC in pregnant women. Determination of half-life, covariates that affect plasma 17-OHPC concentrations, and the modeling of drug behavior provide insights into this drug's pharmacologic properties during multifetal pregnancy.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume205
Issue number1
DOIs
StatePublished - Jul 2011

Fingerprint

17-alpha-Hydroxyprogesterone
Pharmacokinetics
Pregnancy
Half-Life
Drug Design
Parity
African Americans
17-alpha-hydroxy-progesterone caproate
Pregnant Women
Body Mass Index
Pharmaceutical Preparations
Population

Keywords

  • 17-hydroxyprogesterone caproate
  • multifetal gestation
  • pharmacokinetics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Caritis, S. N., Sharma, S., Venkataramanan, R., Rouse, D. J., Peaceman, A. M., Sciscione, A., ... Harper, M. (2011). Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation. American Journal of Obstetrics and Gynecology, 205(1). https://doi.org/10.1016/j.ajog.2011.03.028

Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation. / Caritis, Steve N.; Sharma, Shringi; Venkataramanan, Raman; Rouse, Dwight J.; Peaceman, Alan M.; Sciscione, Anthony; Spong, Catherine Y.; Varner, Michael W.; Malone, Fergal D.; Iams, Jay D.; Mercer, Brian M.; Thorp, John M.; Sorokin, Yoram; Carpenter, Marshall; Lo, Julie; Ramin, Susan; Harper, Margaret.

In: American Journal of Obstetrics and Gynecology, Vol. 205, No. 1, 07.2011.

Research output: Contribution to journalArticle

Caritis, SN, Sharma, S, Venkataramanan, R, Rouse, DJ, Peaceman, AM, Sciscione, A, Spong, CY, Varner, MW, Malone, FD, Iams, JD, Mercer, BM, Thorp, JM, Sorokin, Y, Carpenter, M, Lo, J, Ramin, S & Harper, M 2011, 'Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation', American Journal of Obstetrics and Gynecology, vol. 205, no. 1. https://doi.org/10.1016/j.ajog.2011.03.028
Caritis, Steve N. ; Sharma, Shringi ; Venkataramanan, Raman ; Rouse, Dwight J. ; Peaceman, Alan M. ; Sciscione, Anthony ; Spong, Catherine Y. ; Varner, Michael W. ; Malone, Fergal D. ; Iams, Jay D. ; Mercer, Brian M. ; Thorp, John M. ; Sorokin, Yoram ; Carpenter, Marshall ; Lo, Julie ; Ramin, Susan ; Harper, Margaret. / Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation. In: American Journal of Obstetrics and Gynecology. 2011 ; Vol. 205, No. 1.
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