Pharmacokinetics of cefprozil in infants and children

X. Saez-Llorens, W. C. Shyu, S. Shelton, H. Kumiesz, J. Nelson

Research output: Contribution to journalArticle

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Abstract

Twenty pediatric patients (ages, between 8 months and 8 years) received a single oral dose of cefprozil at levels of 15 and 30 mg/kg of body weight. Cefprozil consists of cis (BMY-28100) and trans (BMY-28167) isomers in an approximately 90:10 ratio. Six plasma samples were collected from each pediatric patient and assayed for drug concentrations. As measured by a microbiological assay, peak concentrations of 11.16 and 15.93 μg of cefprozil per ml occurred at 1 h for patients who received the 15- and 30-mg/kg doses, respectively. The respective mean half-lives of cefprozil were 1.77 and 2.14 h, and the respective mean areas under the curve were 28.05 and 45.28 μg · h/ml for patients who received the 15- and 30-mg/kg doses. When measured by a high-pressure liquid chromatography method, peak concentrations of 12.09 and 18.04 μg of the cis isomer per ml were obtained at 1 h, with mean half-lives of 1.63 and 2.06 h and mean areas under the curve of 30.48 and 49.34 μg · h/ml in patients who received the 15- and 30-mg/kg doses, respectively. For the trans isomer, peak concentrations of 1.16 and 1.63 μg/ml occurred at 1 h, respectively, with mean half-lives of 1.61 and 1.65 h and mean areas under the curve of 2.89 and 4.34 μg · h/ml in patients who received the 15- and 30-mg/kg doses, respectively.

Original languageEnglish (US)
Pages (from-to)2152-2155
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number11
StatePublished - 1990

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Pharmacokinetics
Area Under Curve
Pediatrics
cefprozil
High Pressure Liquid Chromatography
Body Weight
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Saez-Llorens, X., Shyu, W. C., Shelton, S., Kumiesz, H., & Nelson, J. (1990). Pharmacokinetics of cefprozil in infants and children. Antimicrobial Agents and Chemotherapy, 34(11), 2152-2155.

Pharmacokinetics of cefprozil in infants and children. / Saez-Llorens, X.; Shyu, W. C.; Shelton, S.; Kumiesz, H.; Nelson, J.

In: Antimicrobial Agents and Chemotherapy, Vol. 34, No. 11, 1990, p. 2152-2155.

Research output: Contribution to journalArticle

Saez-Llorens, X, Shyu, WC, Shelton, S, Kumiesz, H & Nelson, J 1990, 'Pharmacokinetics of cefprozil in infants and children', Antimicrobial Agents and Chemotherapy, vol. 34, no. 11, pp. 2152-2155.
Saez-Llorens X, Shyu WC, Shelton S, Kumiesz H, Nelson J. Pharmacokinetics of cefprozil in infants and children. Antimicrobial Agents and Chemotherapy. 1990;34(11):2152-2155.
Saez-Llorens, X. ; Shyu, W. C. ; Shelton, S. ; Kumiesz, H. ; Nelson, J. / Pharmacokinetics of cefprozil in infants and children. In: Antimicrobial Agents and Chemotherapy. 1990 ; Vol. 34, No. 11. pp. 2152-2155.
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