Abstract
The pharmacokinetics of orally administered tacrolimus were examined in six female lupus nephritis patients (mean age 43 years, range 24-55 years). Tacrolimus (3 mg) was administered after supper, and blood tacrolimus concentrations were measured just prior to dosing and 1, 2, 4, 6, 8, 12 and 24 h after administration. The maximum blood concentration (Cmax) was observed 4-8 h (mean: 6.7 h) after administration. The mean Cmax and area under the tacrolimus concentrationti-me curve (AUC0-24 h) were 12.7 ng/ml and 163.1 ng·h/ml, respectively. Although there was a weak correlation between AUC0-24 h values and tacrolimus concentrations 2, 4, and 6 h after administration, concentrations at 12 and 24 h were highly correlated with AUC0-24 h values, suggesting that the trough concentration (C24 h) and C12 h are valid markers for therapeutic tacrolimus monitoring. Enzyme-linked immunoabsorbent assay (ELISA) and microparticle enzyme immunoassay (MEIA) measurements of blood tacrolimus concentrations were similar. We recommend that monitoring should be carried out by C12 h in lupus nephritis outpatients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-118 |
| Number of pages | 6 |
| Journal | Yakugaku Zasshi |
| Volume | 130 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2010 |
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Keywords
- Enzyme-linked immunoabsorbent assay (ELISA)
- Lupus nephritis
- Microparticle enzyme immunoassay (MEIA)
- Pharmacokinetics
- Tacrolimus
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Cite this
Pharmacokinetics of orally administered tacrolimus in lupus nephritis patients. / Uchida, Keiko; Asamiya, Yukari; Takei, Takashi; Itabashi, Mitsuyo; Sugiura, Hidekazu; Tsukada, Misao; Nitta, Kosaku.
In: Yakugaku Zasshi, Vol. 130, No. 1, 01.2010, p. 113-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics of orally administered tacrolimus in lupus nephritis patients
AU - Uchida, Keiko
AU - Asamiya, Yukari
AU - Takei, Takashi
AU - Itabashi, Mitsuyo
AU - Sugiura, Hidekazu
AU - Tsukada, Misao
AU - Nitta, Kosaku
PY - 2010/1
Y1 - 2010/1
N2 - The pharmacokinetics of orally administered tacrolimus were examined in six female lupus nephritis patients (mean age 43 years, range 24-55 years). Tacrolimus (3 mg) was administered after supper, and blood tacrolimus concentrations were measured just prior to dosing and 1, 2, 4, 6, 8, 12 and 24 h after administration. The maximum blood concentration (Cmax) was observed 4-8 h (mean: 6.7 h) after administration. The mean Cmax and area under the tacrolimus concentrationti-me curve (AUC0-24 h) were 12.7 ng/ml and 163.1 ng·h/ml, respectively. Although there was a weak correlation between AUC0-24 h values and tacrolimus concentrations 2, 4, and 6 h after administration, concentrations at 12 and 24 h were highly correlated with AUC0-24 h values, suggesting that the trough concentration (C24 h) and C12 h are valid markers for therapeutic tacrolimus monitoring. Enzyme-linked immunoabsorbent assay (ELISA) and microparticle enzyme immunoassay (MEIA) measurements of blood tacrolimus concentrations were similar. We recommend that monitoring should be carried out by C12 h in lupus nephritis outpatients.
AB - The pharmacokinetics of orally administered tacrolimus were examined in six female lupus nephritis patients (mean age 43 years, range 24-55 years). Tacrolimus (3 mg) was administered after supper, and blood tacrolimus concentrations were measured just prior to dosing and 1, 2, 4, 6, 8, 12 and 24 h after administration. The maximum blood concentration (Cmax) was observed 4-8 h (mean: 6.7 h) after administration. The mean Cmax and area under the tacrolimus concentrationti-me curve (AUC0-24 h) were 12.7 ng/ml and 163.1 ng·h/ml, respectively. Although there was a weak correlation between AUC0-24 h values and tacrolimus concentrations 2, 4, and 6 h after administration, concentrations at 12 and 24 h were highly correlated with AUC0-24 h values, suggesting that the trough concentration (C24 h) and C12 h are valid markers for therapeutic tacrolimus monitoring. Enzyme-linked immunoabsorbent assay (ELISA) and microparticle enzyme immunoassay (MEIA) measurements of blood tacrolimus concentrations were similar. We recommend that monitoring should be carried out by C12 h in lupus nephritis outpatients.
KW - Enzyme-linked immunoabsorbent assay (ELISA)
KW - Lupus nephritis
KW - Microparticle enzyme immunoassay (MEIA)
KW - Pharmacokinetics
KW - Tacrolimus
UR - http://www.scopus.com/inward/record.url?scp=74849134691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74849134691&partnerID=8YFLogxK
U2 - 10.1248/yakushi.130.113
DO - 10.1248/yakushi.130.113
M3 - Article
C2 - 20046074
AN - SCOPUS:74849134691
VL - 130
SP - 113
EP - 118
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 1
ER -