TY - JOUR
T1 - Pharmacokinetics of orally administered tacrolimus in lupus nephritis patients
AU - Uchida, Keiko
AU - Asamiya, Yukari
AU - Takei, Takashi
AU - Itabashi, Mitsuyo
AU - Sugiura, Hidekazu
AU - Tsukada, Misao
AU - Nitta, Kosaku
PY - 2010/1
Y1 - 2010/1
N2 - The pharmacokinetics of orally administered tacrolimus were examined in six female lupus nephritis patients (mean age 43 years, range 24-55 years). Tacrolimus (3 mg) was administered after supper, and blood tacrolimus concentrations were measured just prior to dosing and 1, 2, 4, 6, 8, 12 and 24 h after administration. The maximum blood concentration (Cmax) was observed 4-8 h (mean: 6.7 h) after administration. The mean Cmax and area under the tacrolimus concentrationti-me curve (AUC0-24 h) were 12.7 ng/ml and 163.1 ng·h/ml, respectively. Although there was a weak correlation between AUC0-24 h values and tacrolimus concentrations 2, 4, and 6 h after administration, concentrations at 12 and 24 h were highly correlated with AUC0-24 h values, suggesting that the trough concentration (C24 h) and C12 h are valid markers for therapeutic tacrolimus monitoring. Enzyme-linked immunoabsorbent assay (ELISA) and microparticle enzyme immunoassay (MEIA) measurements of blood tacrolimus concentrations were similar. We recommend that monitoring should be carried out by C12 h in lupus nephritis outpatients.
AB - The pharmacokinetics of orally administered tacrolimus were examined in six female lupus nephritis patients (mean age 43 years, range 24-55 years). Tacrolimus (3 mg) was administered after supper, and blood tacrolimus concentrations were measured just prior to dosing and 1, 2, 4, 6, 8, 12 and 24 h after administration. The maximum blood concentration (Cmax) was observed 4-8 h (mean: 6.7 h) after administration. The mean Cmax and area under the tacrolimus concentrationti-me curve (AUC0-24 h) were 12.7 ng/ml and 163.1 ng·h/ml, respectively. Although there was a weak correlation between AUC0-24 h values and tacrolimus concentrations 2, 4, and 6 h after administration, concentrations at 12 and 24 h were highly correlated with AUC0-24 h values, suggesting that the trough concentration (C24 h) and C12 h are valid markers for therapeutic tacrolimus monitoring. Enzyme-linked immunoabsorbent assay (ELISA) and microparticle enzyme immunoassay (MEIA) measurements of blood tacrolimus concentrations were similar. We recommend that monitoring should be carried out by C12 h in lupus nephritis outpatients.
KW - Enzyme-linked immunoabsorbent assay (ELISA)
KW - Lupus nephritis
KW - Microparticle enzyme immunoassay (MEIA)
KW - Pharmacokinetics
KW - Tacrolimus
UR - http://www.scopus.com/inward/record.url?scp=74849134691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74849134691&partnerID=8YFLogxK
U2 - 10.1248/yakushi.130.113
DO - 10.1248/yakushi.130.113
M3 - Comment/debate
C2 - 20046074
AN - SCOPUS:74849134691
SN - 0031-6903
VL - 130
SP - 113
EP - 118
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
IS - 1
ER -