Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients

J. D. Nelson; H. Kusmiesz; S. Shelton

doi:10.1128/AAC.21.4.681

Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients

J. D. Nelson, H. Kusmiesz, S. Shelton

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Two dosages of a liquid suspension formulation of amoxicillin and potassium clavulanate were tested in 34 infants and children. The smaller dosage resulted in suboptimal plasma concentrations. With the greater dosage (3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg), the mean peak plasma concentrations were 1.6 μg clavulanic acid per ml and 4.9 μg amoxicillin per ml.

Original language	English (US)
Pages (from-to)	681-682
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	21
Issue number	4
DOIs	https://doi.org/10.1128/AAC.21.4.681
State	Published - 1982

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Two dosages of a liquid suspension formulation of amoxicillin and potassium clavulanate were tested in 34 infants and children. The smaller dosage resulted in suboptimal plasma concentrations. With the greater dosage (3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg), the mean peak plasma concentrations were 1.6 μg clavulanic acid per ml and 4.9 μg amoxicillin per ml.",

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AB - Two dosages of a liquid suspension formulation of amoxicillin and potassium clavulanate were tested in 34 infants and children. The smaller dosage resulted in suboptimal plasma concentrations. With the greater dosage (3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg), the mean peak plasma concentrations were 1.6 μg clavulanic acid per ml and 4.9 μg amoxicillin per ml.

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Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients

Abstract

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