Pharmacological evidence for a role of γ-aminobutyric acid A receptor mechanism in modulating nitric oxide synthase activity in rat brain

Vanaja Paul, E. Harihara Subramanian, Karthik Rajasekaran

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The role of γ-aminobutyric acid (GABA) mechanism on the synthesis of nitric oxide (NO) has been investigated by measuring the activity of nitric oxide synthase (NOS) and the concentration of NO in rat brain 15 min after administration of anticonvulsant doses of diazepam (0.25 and 0.5 mg/kg) which is known to activate GABA A receptor for its anticonvulsant action. Diazepam enhanced both NOS activity and the concentration of NO in a dose-dependent manner. A reversal has been observed in animals treated with a convulsant dose of picrotoxin (5 mg/kg) which is known to produce convulsions by blocking GABA A receptor mechanism. These results suggest that a functional interaction occurs between GABA A receptor activity and NO synthesis in the brain. (C) 2001 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)209-211
Number of pages3
JournalNeurochemistry International
Volume38
Issue number3
DOIs
StatePublished - 2001

Fingerprint

Aminobutyrates
Nitric Oxide Synthase
Nitric Oxide
GABA-A Receptors
Pharmacology
Brain
Diazepam
Anticonvulsants
Convulsants
Picrotoxin
gamma-Aminobutyric Acid
Seizures

Keywords

  • Diazepam
  • GABA A receptor
  • Nitric oxide
  • Picrotoxin

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Pharmacological evidence for a role of γ-aminobutyric acid A receptor mechanism in modulating nitric oxide synthase activity in rat brain. / Paul, Vanaja; Subramanian, E. Harihara; Rajasekaran, Karthik.

In: Neurochemistry International, Vol. 38, No. 3, 2001, p. 209-211.

Research output: Contribution to journalArticle

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