Phenotypic characterization of autoreactive T cells in multiple sclerosis

Robert B. Ratts, Nitin J. Karandikar, Rehana Z. Hussain, Judy Choy, Sara C. Northrop, Amy E. Lovett-Racke, Michael K. Racke

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


MS has been hypothesized to result from autoreactive T cell responses against myelin antigens. In this report, we examined myelin-specific CD8 and CD4 T cells for two markers differentially expressed on naïve, memory and chronically stimulated T cells, CD28 and CD57. We observed differential expression on CD8 T cells in response to myelin antigens, but not in response to the recall antigen mumps. We demonstrate these cells display reduced proliferation and this may explain why therapies that limit the proliferation of T cells have had little effect on the course of MS, particularly later in the course of the disease.

Original languageEnglish (US)
Pages (from-to)100-110
Number of pages11
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - Sep 2006


  • Autoimmunity
  • CD81
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Phenotypic characterization of autoreactive T cells in multiple sclerosis'. Together they form a unique fingerprint.

Cite this