Phosphatidylinositol phosphate kinase: A link between protein kinase and glutathione synthase folds

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39 Scopus citations

Abstract

Comparisons of serine/threonine protein kinase (PK) and type IIβ phosphatidylinositol phosphate kinase (PIPK) structures with each other and also with other proteins reveal structural and functional similarity between the two kinases and proteins of the glutathione synthase fold (ATP-grasp). This suggests that these enzymes are evolutionarily related. The structure of PIPK, which clearly resembles both PK and ATP-grasp, provides a link between the two proteins and establishes that the C-terminal domains of PK, PIPK and ATP-grasp share the same fold. The functional implications of the proposed homology are discussed.

Original languageEnglish (US)
Pages (from-to)239-247
Number of pages9
JournalJournal of Molecular Biology
Volume291
Issue number2
DOIs
StatePublished - Aug 13 1999

Keywords

  • ATP-grasp fold
  • Fold evolution
  • Lipid kinase
  • Protein kinase
  • SAICAR synthase

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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