Photoimmunology

Jake E. Turrentine, Ponciano D Cruz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Photoimmunology is the study of the effects of non-ionizing electromagnetic radiation (principally ultraviolet light) on the immune system. Ultraviolet (UV) light represents the spectrum of electromagnetic radiation between the wavelengths of 100 and 400 nm. Through its actions on the immune system, UV radiation promotes the development of skin cancers, modulates the development of allergic contact dermatitis, and triggers several specific photosensitivity disorders collectively known as the immunologically-mediated photodermatoses. These disorders include polymorphic light eruption, actinic prurigo, solar urticaria, hydro vacciniforme, and chronic actinic dermatitis. In addition to discussing the molecular underpinnings of UV-induced carcinogenesis and the effects of UV radiation on contact hypersensitivy responses, this chapter reviews the clinical features, epidemiology, pathophysiology and treatment of the immunologically-mediated photodermatoses. Additionally, this chapter highlights the key immunologic mechanisms by which UV radiation is used therapeutically to treat dermatologic diseases, especially T-cell mediated skin disorders.

Original languageEnglish (US)
Title of host publicationClinical and Basic Immunodermatology
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Pages151-163
Number of pages13
ISBN (Electronic)9783319297859
ISBN (Print)9783319297835
DOIs
StatePublished - Apr 24 2017

Fingerprint

Electromagnetic Radiation
Photosensitivity Disorders
Ultraviolet Rays
Immune System
Nonionizing Radiation
Radiation
Allergic Contact Dermatitis
Radiation Effects
Urticaria
Skin Neoplasms
Carcinogenesis
Epidemiology
T-Lymphocytes
Light
Skin
Actinic Prurigo

Keywords

  • Actinic prurigo
  • Chronic actinic dermatitis
  • Hydroa vacciniforme
  • Photoimmunology
  • Photoimmunosuppression
  • Phototherapy
  • Polymorphic light eruption
  • Solar urticaria
  • Ultraviolet light
  • Ultraviolet radiation

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Turrentine, J. E., & Cruz, P. D. (2017). Photoimmunology. In Clinical and Basic Immunodermatology: Second Edition (pp. 151-163). Springer International Publishing. https://doi.org/10.1007/978-3-319-29785-9_10

Photoimmunology. / Turrentine, Jake E.; Cruz, Ponciano D.

Clinical and Basic Immunodermatology: Second Edition. Springer International Publishing, 2017. p. 151-163.

Research output: Chapter in Book/Report/Conference proceedingChapter

Turrentine, JE & Cruz, PD 2017, Photoimmunology. in Clinical and Basic Immunodermatology: Second Edition. Springer International Publishing, pp. 151-163. https://doi.org/10.1007/978-3-319-29785-9_10
Turrentine JE, Cruz PD. Photoimmunology. In Clinical and Basic Immunodermatology: Second Edition. Springer International Publishing. 2017. p. 151-163 https://doi.org/10.1007/978-3-319-29785-9_10
Turrentine, Jake E. ; Cruz, Ponciano D. / Photoimmunology. Clinical and Basic Immunodermatology: Second Edition. Springer International Publishing, 2017. pp. 151-163
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