Pituitary size in depression

K. Ranga Rama Krishnan, P. Murali Doraiswamy, Scott N. Lurie, Gary S. Figiel, Mustafa M. Husain, Orest B. Boyko, Everett H. Ellinwood, Charles B. Nemeroff

Research output: Contribution to journalArticle

169 Scopus citations


Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age-and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

Original languageEnglish (US)
Pages (from-to)256-259
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number2
StatePublished - Feb 1991


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Krishnan, K. R. R., Doraiswamy, P. M., Lurie, S. N., Figiel, G. S., Husain, M. M., Boyko, O. B., Ellinwood, E. H., & Nemeroff, C. B. (1991). Pituitary size in depression. Journal of Clinical Endocrinology and Metabolism, 72(2), 256-259. https://doi.org/10.1210/jcem-72-2-256