Pituitary size in depression

K. Ranga Rama Krishnan; P. Murali Doraiswamy; Scott N. Lurie; Gary S. Figiel; Mustafa M. Husain; Orest B. Boyko; Everett H. Ellinwood; Charles B. Nemeroff

Pituitary size in depression

K. Ranga Rama Krishnan, P. Murali Doraiswamy, Scott N. Lurie, Gary S. Figiel, Mustafa M. Husain, Orest B. Boyko, Everett H. Ellinwood, Charles B. Nemeroff

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Abstract

Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age-and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

Original language	English (US)
Pages (from-to)	256-259
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	72
Issue number	2
State	Published - Feb 1991

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

Cite this

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abstract = "Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age-and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.",

author = "Krishnan, {K. Ranga Rama} and Doraiswamy, {P. Murali} and Lurie, {Scott N.} and Figiel, {Gary S.} and Husain, {Mustafa M.} and Boyko, {Orest B.} and Ellinwood, {Everett H.} and Nemeroff, {Charles B.}",

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AU - Krishnan, K. Ranga Rama

AU - Doraiswamy, P. Murali

AU - Lurie, Scott N.

AU - Figiel, Gary S.

AU - Husain, Mustafa M.

AU - Boyko, Orest B.

AU - Ellinwood, Everett H.

AU - Nemeroff, Charles B.

PY - 1991/2

Y1 - 1991/2

N2 - Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age-and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

AB - Magnetic resonance images centered at the pituitary stalk were used to measure pituitary gland size in 19 patients with major depression compared with that in age-and sex-matched controls. Depressed patients had significantly greater pituitary cross-sectional area (P = 0.0009) and volume (P = 0.007) than the controls. This difference was particularly prominent in elderly depressed patients compared to elderly controls. These results provide the first demonstration of structural alterations in the pituitary gland in major depression.

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JF - Journal of Clinical Endocrinology and Metabolism

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ER -

Pituitary size in depression

Abstract

ASJC Scopus subject areas

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