Plasma and erythrocyte lipids in sickle cell anaemia

J. Sasaki, M. R. Waterman, G. R. Buchanan, G. L. Cottam

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26 Scopus citations


The content and composition of plasma and erythrocyte lipids from individuals having sickle cell anaemia has been determined. The plasma contains a significantly reduced content of both cholesterol and phospholipid while the ratio of cholesteryl ester to total cholesterol, the distribution of phospholipid classes, triglyceride concentration and the fatty acid content were similar to normal values. However, the free glycerol content of the plasma was eight-fold higher than normal. Erythrocyte lipids contain an elevated level of cholesterol and control levels of phospholipid content, phospholipid distribution and fatty acid content. The plasma was separated by ultracentrifugation into VLDL (density < 1.006), LDL (1.006 < d < 1.063) and HDL (1.063 < d < 1.21). Significant decreases in cholesterol and phospholipid were observed in LDL and HDL.

Original languageEnglish (US)
Pages (from-to)35-44
Number of pages10
JournalClinical and Laboratory Haematology
Issue number1
Publication statusPublished - 1983


ASJC Scopus subject areas

  • Hematology

Cite this

Sasaki, J., Waterman, M. R., Buchanan, G. R., & Cottam, G. L. (1983). Plasma and erythrocyte lipids in sickle cell anaemia. Clinical and Laboratory Haematology, 5(1), 35-44.