Plasma and erythrocyte lipids in sickle cell anaemia

J. Sasaki, M. R. Waterman, G. R. Buchanan, G. L. Cottam

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Abstract

The content and composition of plasma and erythrocyte lipids from individuals having sickle cell anaemia has been determined. The plasma contains a significantly reduced content of both cholesterol and phospholipid while the ratio of cholesteryl ester to total cholesterol, the distribution of phospholipid classes, triglyceride concentration and the fatty acid content were similar to normal values. However, the free glycerol content of the plasma was eight-fold higher than normal. Erythrocyte lipids contain an elevated level of cholesterol and control levels of phospholipid content, phospholipid distribution and fatty acid content. The plasma was separated by ultracentrifugation into VLDL (density < 1.006), LDL (1.006 < d < 1.063) and HDL (1.063 < d < 1.21). Significant decreases in cholesterol and phospholipid were observed in LDL and HDL.

Original languageEnglish (US)
Pages (from-to)35-44
Number of pages10
JournalClinical and Laboratory Haematology
Volume5
Issue number1
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Hematology

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Sasaki, J., Waterman, M. R., Buchanan, G. R., & Cottam, G. L. (1983). Plasma and erythrocyte lipids in sickle cell anaemia. Clinical and Laboratory Haematology, 5(1), 35-44.