Plasma and erythrocyte lipids in sickle cell anaemia

J. Sasaki, M. R. Waterman, G. R. Buchanan, G. L. Cottam

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Summary. The content and composition of plasma and erythrocyte lipids from individuals having sickle cell anaemia has been determined. The plasma contains a significantly reduced content of both cholesterol and phospholipid while the ratio of cholesteryl ester to total cholesterol, the distribution of phospholipids classes, triglyceride concentration and the fatty acid content were similar to normal values. However, the free glycerol content of the plasma was eight‐fold higher than normal. Erythrocyte lipids contain an elevated level of cholesterol and control levels of phospholipid content, phospholipid distribution and fatty acid content. The plasma was separated by ultracentrifugation into VLDL (density <1.006), LDL (1.006< d <1.063) and HDL (1.063< d< 1.21). Significant decreases in cholesterol and phospholipid were observed in LDL and HDL.

Original languageEnglish (US)
Pages (from-to)35-44
Number of pages10
JournalClinical & Laboratory Haematology
Volume5
Issue number1
DOIs
StatePublished - Mar 1983

Keywords

  • erythrocyte lipids
  • plasma lipids
  • sickle cell anaemia

ASJC Scopus subject areas

  • Hematology

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