Platelet-activating factor-acetylhydrolase activity in normotensive and hypertensive pregnancies

N. Maki, R. R. Magness, S. Miyaura, N. F. Gant, J. M. Johnston

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: The purpose of our study was to evaluate the hypothesis that pregnancy is associated with decreased platelet-activating factor-acetylhydrolase activity in women with normotension, but not in women with hypertension. Study design: We evaluated plasma platelet-activating factor-acetylhydrolase activity in normal nonpregnant women (n = 10), normal pregnant women (n = 24), pregnant women with pregnancy-induced hypertension-preeclampsia (n = 7), and a group of men with normotension (n = 10). Results: Platelet-activating factor-acetylhydrolase activity was lower at 32 weeks of gestation during normal pregnancies compared with nonpregnant controls (p < 0.001); however, in women with pregnancy-induced hypertension-preeclampsia, platelet-activating factor-acetylhydrolase activity was not decreased. Platelet-activating factor-acetylhydrolase activity in men was higher than in all women (p < 0.01). Conclusion: Pregnant women with normotension may be refractory to pressor agents such as angiotensin II in part because of the decrease in plasma platelet-activating factor-acetylhydrolase activity, which results in an increase in platelet-activating factor. In contrast, enzyme activity is not decreased in pregnant women with hypertension, who have increased sensitivity to various pressor agents.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume168
Issue number1 I
StatePublished - 1993

Fingerprint

Platelet Activating Factor
Pregnancy
Pregnant Women
Pregnancy Induced Hypertension
Pre-Eclampsia
Hypertension
Angiotensin II
Enzymes

Keywords

  • estrogens
  • platelet-activating factor-acetylhydrolase
  • preeclampsia
  • smoking

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Maki, N., Magness, R. R., Miyaura, S., Gant, N. F., & Johnston, J. M. (1993). Platelet-activating factor-acetylhydrolase activity in normotensive and hypertensive pregnancies. American Journal of Obstetrics and Gynecology, 168(1 I), 50-54.

Platelet-activating factor-acetylhydrolase activity in normotensive and hypertensive pregnancies. / Maki, N.; Magness, R. R.; Miyaura, S.; Gant, N. F.; Johnston, J. M.

In: American Journal of Obstetrics and Gynecology, Vol. 168, No. 1 I, 1993, p. 50-54.

Research output: Contribution to journalArticle

Maki, N, Magness, RR, Miyaura, S, Gant, NF & Johnston, JM 1993, 'Platelet-activating factor-acetylhydrolase activity in normotensive and hypertensive pregnancies', American Journal of Obstetrics and Gynecology, vol. 168, no. 1 I, pp. 50-54.
Maki, N. ; Magness, R. R. ; Miyaura, S. ; Gant, N. F. ; Johnston, J. M. / Platelet-activating factor-acetylhydrolase activity in normotensive and hypertensive pregnancies. In: American Journal of Obstetrics and Gynecology. 1993 ; Vol. 168, No. 1 I. pp. 50-54.
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