Platelet-activating factor-acetylhydrolase activity in normotensive and hypertensive pregnancies

N. Maki, R. R. Magness, S. Miyaura, N. F. Gant, J. M. Johnston

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Objective: The purpose of our study was to evaluate the hypothesis that pregnancy is associated with decreased platelet-activating factor-acetylhydrolase activity in women with normotension, but not in women with hypertension. Study Design: We evaluated plasma platelet-activating factor-acetylhydrolase activity in normal nonpregnant women (n = 10), normal pregnant women (n = 24), pregnant women with pregnancy-induced hypertension-preeclampsia (n = 7), and a group of men with normotension (n =10). Results: Platelet-activating factor-acetylhydrolase activity was lower at 32 weeks of gestation during normal pregnancies compared with nonpregnant controls (p < 0.001); however, in women with pregnancy-induced hypertension-preeclampsia, platelet-activating factor-acetylhydrolase activity was not decreased. Platelet-activating factor-acetylhydrolase activity in men was higher than in all women (p < 0.01). Conclusion: Pregnant women with normotension may be refractory to pressor agents such as angiotensin II in part because of the decrease in plasma platelet-activating factor-acetylhydrolase activity, which results in an increase in platelet-activating factor. In contrast, enzyme activity is not decreased in pregnant women with hypertension, who have increased sensitivity to various pressor agents.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume168
Issue number1
DOIs
StatePublished - 1993

Keywords

  • Platelet-activating factor-acetylhydrolase
  • estrogens
  • preeclampsia
  • smoking

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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