Platelet attachment and spreading on polystyrene surfaces: Dependence on fibronectin and plasma concentration

Frederick Grinnell, Trung V. Phan

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Fibronectin promoted platelet attachment and spreading on polystyrene surfaces but was not essential if the surfaces were coated with plasma. The dependence of platelet adhesion on plasma concentration was complex. The extent of attachment and spreading was increased on surfaces treated with up to 1.0% plasma and decreased at higher plasma concentrations. The results support the hypothesis that protein adsorption is not directly related to protein concentration when surfaces are exposed to complex protein mixtures.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalThrombosis research
Volume39
Issue number2
DOIs
StatePublished - Jul 15 1985

Keywords

  • Platelet adhesion
  • fibronectin
  • plasma

ASJC Scopus subject areas

  • Hematology

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