Platelet attachment and spreading on polystyrene surfaces: Dependence on fibronectin and plasma concentration

Frederick Grinnell; Trung V. Phan

doi:10.1016/0049-3848(85)90104-5

Platelet attachment and spreading on polystyrene surfaces: Dependence on fibronectin and plasma concentration

Frederick Grinnell, Trung V. Phan

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Fibronectin promoted platelet attachment and spreading on polystyrene surfaces but was not essential if the surfaces were coated with plasma. The dependence of platelet adhesion on plasma concentration was complex. The extent of attachment and spreading was increased on surfaces treated with up to 1.0% plasma and decreased at higher plasma concentrations. The results support the hypothesis that protein adsorption is not directly related to protein concentration when surfaces are exposed to complex protein mixtures.

Original language	English (US)
Pages (from-to)	165-171
Number of pages	7
Journal	Thrombosis research
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/0049-3848(85)90104-5
State	Published - Jul 15 1985

Keywords

Platelet adhesion
fibronectin
plasma

ASJC Scopus subject areas

Hematology

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10.1016/0049-3848(85)90104-5

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title = "Platelet attachment and spreading on polystyrene surfaces: Dependence on fibronectin and plasma concentration",

abstract = "Fibronectin promoted platelet attachment and spreading on polystyrene surfaces but was not essential if the surfaces were coated with plasma. The dependence of platelet adhesion on plasma concentration was complex. The extent of attachment and spreading was increased on surfaces treated with up to 1.0% plasma and decreased at higher plasma concentrations. The results support the hypothesis that protein adsorption is not directly related to protein concentration when surfaces are exposed to complex protein mixtures.",

keywords = "Platelet adhesion, fibronectin, plasma",

author = "Frederick Grinnell and Phan, {Trung V.}",

note = "Funding Information: Ths research was supported by a grant from the NIH, HL24221.",

year = "1985",

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T1 - Platelet attachment and spreading on polystyrene surfaces

T2 - Dependence on fibronectin and plasma concentration

AU - Grinnell, Frederick

AU - Phan, Trung V.

N1 - Funding Information: Ths research was supported by a grant from the NIH, HL24221.

PY - 1985/7/15

Y1 - 1985/7/15

N2 - Fibronectin promoted platelet attachment and spreading on polystyrene surfaces but was not essential if the surfaces were coated with plasma. The dependence of platelet adhesion on plasma concentration was complex. The extent of attachment and spreading was increased on surfaces treated with up to 1.0% plasma and decreased at higher plasma concentrations. The results support the hypothesis that protein adsorption is not directly related to protein concentration when surfaces are exposed to complex protein mixtures.

AB - Fibronectin promoted platelet attachment and spreading on polystyrene surfaces but was not essential if the surfaces were coated with plasma. The dependence of platelet adhesion on plasma concentration was complex. The extent of attachment and spreading was increased on surfaces treated with up to 1.0% plasma and decreased at higher plasma concentrations. The results support the hypothesis that protein adsorption is not directly related to protein concentration when surfaces are exposed to complex protein mixtures.

KW - Platelet adhesion

KW - fibronectin

KW - plasma

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JO - Thrombosis research

JF - Thrombosis research

IS - 2

ER -

Platelet attachment and spreading on polystyrene surfaces: Dependence on fibronectin and plasma concentration

Abstract

Keywords

ASJC Scopus subject areas

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