Pneumococcal Surface Protein C Contributes to Sepsis Caused by Streptococcus pneumoniae in Mice

Francesco Iannelli, Damiana Chiavolini, Susanna Ricci, Marco Rinaldo Oggioni, Gianni Pozzi

Research output: Contribution to journalArticle

58 Scopus citations


The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.

Original languageEnglish (US)
Pages (from-to)3077-3080
Number of pages4
JournalInfection and immunity
Issue number5
StatePublished - May 1 2004


ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this