Polar spongioblastoma of the spinal cord: A case report

Christine Fuller, Kathleen Helton, James Dalton, Maryam Fouladi, Larry Kun, Peter Burger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

"Rhythmic palisading" is a striking histologic pattern infrequently encountered in a variety of central nervous system (CNS) tumors. We present the case of an infant with a large spinal cord lesion wherein all sampled tissue showed columnar arrangements of palisaded cells, typical of polar spongioblastoma. The tumor was briskly proliferative, focally necrotic, and variably expressed S100, glial fibrillary acidic protein, neuron specific enolase, and p53 by immunohistochemistry. Fluorescence in situ hybridization failed to reveal isochromosome 17q, EGFR amplification, or deletions of 1p, 19q, 22q11.2, 10q, or p16. Despite chemotherapy and decadron, he developed lesional necrosis and intracranial metastases and died less than 1 mo from presentation. This case illustrates polar spongioblastoma as a distinctive histologic pattern that can occur in embryonal CNS tumors. Discrimination of these rare aggressive lesions from other CNS tumors with focal palisaded architecture is crucial as the treatment and prognosis of the latter may differ significantly.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalPediatric and Developmental Pathology
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2006

Fingerprint

Neuroepithelial Neoplasms
Central Nervous System Neoplasms
Spinal Cord
Isochromosomes
Phosphopyruvate Hydratase
Glial Fibrillary Acidic Protein
Fluorescence In Situ Hybridization
Dexamethasone
Necrosis
Immunohistochemistry
Neoplasm Metastasis
Drug Therapy
Neoplasms
Therapeutics

Keywords

  • Fluorescence in situ hybridization (FISH)
  • Immunohistochemistry
  • Pediatric
  • Polar spongioblastoma
  • Spinal cord

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Fuller, C., Helton, K., Dalton, J., Fouladi, M., Kun, L., & Burger, P. (2006). Polar spongioblastoma of the spinal cord: A case report. Pediatric and Developmental Pathology, 9(1), 75-80. https://doi.org/10.2350/08-05-0099.1

Polar spongioblastoma of the spinal cord : A case report. / Fuller, Christine; Helton, Kathleen; Dalton, James; Fouladi, Maryam; Kun, Larry; Burger, Peter.

In: Pediatric and Developmental Pathology, Vol. 9, No. 1, 01.01.2006, p. 75-80.

Research output: Contribution to journalArticle

Fuller, C, Helton, K, Dalton, J, Fouladi, M, Kun, L & Burger, P 2006, 'Polar spongioblastoma of the spinal cord: A case report', Pediatric and Developmental Pathology, vol. 9, no. 1, pp. 75-80. https://doi.org/10.2350/08-05-0099.1
Fuller, Christine ; Helton, Kathleen ; Dalton, James ; Fouladi, Maryam ; Kun, Larry ; Burger, Peter. / Polar spongioblastoma of the spinal cord : A case report. In: Pediatric and Developmental Pathology. 2006 ; Vol. 9, No. 1. pp. 75-80.
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