TY - JOUR
T1 - Polygenic control of susceptibility to murine systemic lupus erythematosus
AU - Morel, Laurence
AU - Rudofsky, Ulrich H.
AU - Longmate, Jeffrey A.
AU - Schiffenbauer, Joel
AU - Wakeland, Edward K.
N1 - Funding Information:
We are indebted to Dr. A. E. Gabrielsen, who developed the NZMi Aeg strains and who perceived their value in the study of SLE at the outset of the breeding program in 1981. We thank E. Butfiloski and L. McDowell for excellent technical assistance. This work was supported by National Institutes of Health grants to E. K. W. (Al17966, GM39578, HL47138). L. M. is a recipient of National Research Service Award fellowship (F32A108801) from the National Institutes of Health
PY - 1994/6
Y1 - 1994/6
N2 - Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GN susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system.
AB - Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GN susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system.
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U2 - 10.1016/1074-7613(94)90100-7
DO - 10.1016/1074-7613(94)90100-7
M3 - Article
C2 - 7889410
AN - SCOPUS:0028445340
SN - 1074-7613
VL - 1
SP - 219
EP - 229
JO - Immunity
JF - Immunity
IS - 3
ER -