Poly(L-lysine)-graft-dextran copolymer is a novel stabilizer of triplex DNA (I): stabilization of poly(dA).2poly(dT) triplex.

A. Maruyama, H. Watanabe, A. Ferdous, T. Akaike

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Comb-type polylysine copolymer having grafted hydrophilic side chains was newly designed as a novel stabilizer of triplex DNAs. The comb-type copolymer elevated melting temperature of poly(dA).2poly(dT) triplex by 50 degrees C without affecting reversibility, melting and reassociation, of the triplex in buffer with physiological salt concentrations. The stabilizing effect of the copolymer was greater than spermine. Our results indicate that the molecular designing of polycation with comb-type structure is a successful strategy for creating an effective triplex stabilizer.

Original languageEnglish (US)
Pages (from-to)225-226
Number of pages2
JournalNucleic acids symposium series
Issue number37
StatePublished - 1997

ASJC Scopus subject areas

  • Medicine(all)

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