Polymeric nanoparticulate drug delivery through the blood brain barrier

Celeste Roney, Padmakar Kulkarni, Veera Arora, Michael Bennett, Peter Antich, Frederick Bonte, Aimei Wu, N. N. Mallikarjuna, Sanjeev Manohar, Malladi Sairam, Tejraj M. Aminabhavi

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Alzheimer's disease (AD) is the most common cause of dementia among the elderly, affecting 5% of Americans over age 65, and 20% over age 80. An excess of senile plaques (β-amyloid protein) and neurofibrillary tangles (tau protein), ventricular enlargement, and cortical atrophy characterizes it. Unfortunately, targeted drug delivery to the Central Nervous System (CNS), for the therapeutic advancement of neurodegenerative disorders such as Alzheimer's, is complicated by restrictive mechanisms imposed at the blood brain barrier (BBB). Opsonization by plasma proteins in the systemic circulation is an additional impediment to cerebral drug delivery. Here, we attempt to show that biodegradable polymeric nanoparticles (NPs) with appropriate surface modifications can deliver drugs of interest beyond the BBB for diagnostic and therapeutic applications, thus allowing the study of neurological disorders. Particularly, the radiolabelled Cu2+ or Fe3+ metal chelator Clioquinol (CQ), which has a high affinity for amyloid plaques with a radio-isotope 125I, and encapsulated 125I-CQ within small, spherical, lipophilic drug carriers are capable of crossing the BBB. In this feature article, the biodistribution patterns of such nanoparticle drug carriers in wild type Swiss Webster mice are compared with free 125I-CQ. The physicochemical properties of the NPs at different surfactant concentrations, stabilizers, and amyloid-affinity agents could influence the transport mechanism.

Original languageEnglish (US)
Pages (from-to)311-321
Number of pages11
JournalPolymer News
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2005

Keywords

  • AD metallobiology
  • Alzheimer's disease
  • Amyloid-beta protein
  • Blood brain barrier
  • Clioquinol

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Polymers and Plastics

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  • Cite this

    Roney, C., Kulkarni, P., Arora, V., Bennett, M., Antich, P., Bonte, F., Wu, A., Mallikarjuna, N. N., Manohar, S., Sairam, M., & Aminabhavi, T. M. (2005). Polymeric nanoparticulate drug delivery through the blood brain barrier. Polymer News, 30(10), 311-321. https://doi.org/10.1080/00323910500290374