Abstract
To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.
Original language | English (US) |
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Pages (from-to) | 639-649 |
Number of pages | 11 |
Journal | Immunogenetics |
Volume | 56 |
Issue number | 9 |
DOIs | |
State | Published - Dec 2004 |
Keywords
- Cytotoxic T lymphocyte
- H2-Qa1
- H2-T23
- MHC class Ib
- Mus spretus
- Wild mice
ASJC Scopus subject areas
- Immunology
- Genetics