Polymorphism and conservation of the genes encoding Qa1 molecules

Evan Hermel, Andrew J. Hart, Irfan Gunduz, Hector Acton, Christina Kim, Mark Wurth, Samina Uddin, Caryn Smith, Kirsten Fischer Lindahl, Carla J. Aldrich

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.

Original languageEnglish (US)
Pages (from-to)639-649
Number of pages11
JournalImmunogenetics
Volume56
Issue number9
DOIs
StatePublished - Dec 1 2004

Keywords

  • Cytotoxic T lymphocyte
  • H2-Qa1
  • H2-T23
  • MHC class Ib
  • Mus spretus
  • Wild mice

ASJC Scopus subject areas

  • Immunology
  • Genetics

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    Hermel, E., Hart, A. J., Gunduz, I., Acton, H., Kim, C., Wurth, M., Uddin, S., Smith, C., Lindahl, K. F., & Aldrich, C. J. (2004). Polymorphism and conservation of the genes encoding Qa1 molecules. Immunogenetics, 56(9), 639-649. https://doi.org/10.1007/s00251-004-0722-x