@article{80973bad912e4af297d6d32c3dfd79d5,
title = "pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos",
abstract = "In C. elegans embryogenesis, the MS blastomere produces predominantly mesodermal cell types, while its sister E generates only endodermal tissue. We show that a maternal gene, pop-1, is essential for the specification of MS fate and that a mutation in pop-1 results in MS adopting an E fate. Previous studies have shown that the maternal gene skn-1 is required for both MS and E development and that skn-1 encodes a transcription factor. We show here that the pop-1 gene encodes a protein with an HMG box similar to the HMG boxes in the vertebrate lymphoid-specifictranscriptional regulators TCF-1 and LEF-1. We propose that POP-1 and SKN-1 function together in the early embryo to allow MS-specific differentiation.",
author = "Rueyling Lin and Samantha Thompson and Priess, {James R.}",
note = "Funding Information: We thank Mike Costa, Karla Neugebauer, William Downs, Barbara Page, and Caroline Goutte for comments on the manuscript and Eric Lambie for communicating unpublished mapping data. The C. elegans Genome Project provided cosmid clones and the Caenorhabditis Genetic Center (supported by the National Institutes of Health [NIH] National Center for Research Resources) provided several nematode strains. We thank members of the Priess laboratory for helpful discussions in the course of this work and Heather Cheng for technical assistance. The authors are particularly grateful for, and will miss in the future, the interest, insight, and enthusiasm of Harold Weintraub. J. R. P. was supported by the Howard Hughes Medical Institute (HHMI) and a grant from the NIH, S. T. by the HHMI, and R. L. by a Muscular Dystrophy Association fellowship.",
year = "1995",
month = nov,
day = "17",
doi = "10.1016/0092-8674(95)90100-0",
language = "English (US)",
volume = "83",
pages = "599--609",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",
}