pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos

Rueyling Lin, Samantha Thompson, James R. Priess

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

In C. elegans embryogenesis, the MS blastomere produces predominantly mesodermal cell types, while its sister E generates only endodermal tissue. We show that a maternal gene, pop-1, is essential for the specification of MS fate and that a mutation in pop-1 results in MS adopting an E fate. Previous studies have shown that the maternal gene skn-1 is required for both MS and E development and that skn-1 encodes a transcription factor. We show here that the pop-1 gene encodes a protein with an HMG box similar to the HMG boxes in the vertebrate lymphoid-specifictranscriptional regulators TCF-1 and LEF-1. We propose that POP-1 and SKN-1 function together in the early embryo to allow MS-specific differentiation.

Original languageEnglish (US)
Pages (from-to)599-609
Number of pages11
JournalCell
Volume83
Issue number4
DOIs
StatePublished - Nov 17 1995

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HMGB Proteins
Mesoderm
Embryonic Structures
Genes
Specifications
Mothers
Blastomeres
Embryonic Development
Vertebrates
Transcription Factors
Tissue
Mutation
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology
  • Molecular Biology

Cite this

pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos. / Lin, Rueyling; Thompson, Samantha; Priess, James R.

In: Cell, Vol. 83, No. 4, 17.11.1995, p. 599-609.

Research output: Contribution to journalArticle

Lin, Rueyling ; Thompson, Samantha ; Priess, James R. / pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos. In: Cell. 1995 ; Vol. 83, No. 4. pp. 599-609.
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