Post-renal transplantation hypophosphatemia: A review and novel insights

Hrishikesh Ghanekar, Brian J. Welch, Orson W. Moe, Khashayar Sakhaee

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Purpose of review: This review intends to elucidate the pathophysiologic mechanism of renal phosphorus loss in the post-renal transplantation population. This review will provide new insight in to the pathophysiologic mechanism(s) responsible for the development of this phenomenon and will also explore the pathogenetic role of persistent phosphorus wasting in the development of post-renal transplantation osteodystrophy. Recent findings: Recently, the phosphaturic hormone, fibroblast growth factor-23, has been ascertain to be increased in the sera of patients with chronic kidney and end-stage renal disease. There is new evidence that a non-PTH humoral factor is persistently present in post-renal transplantation patients that is likely responsible for the observed persistent renal phosphorus loss. We offer that fibroblast growth factor-23 (and/or other phosphatonins) is the culprit factor responsible for the phenomenon of persistent hypophosphatemia in post-renal transplantation patients. Moreover, we believe that the phenomenon of persistent renal phosphorus wasting is an important but overlooked cause of osteodystrophy and increased fracture risk in this patient population. Summary: The pathophysiology of post-renal transplantation phosphorus wasting is complex and to date is still not fully recognized. Further studies of the regulatory mechanism of fibroblast growth factor-23 and its metabolism may offer additional insights into phosphorus homeostasis and its clinical application in the post-renal transplantation population.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalCurrent opinion in nephrology and hypertension
Volume15
Issue number2
DOIs
StatePublished - Mar 1 2006

Keywords

  • Fibroblast growth factor-23
  • Hypophosphatemia
  • Osteodystrophy
  • Prostaglandin E
  • Renal transplantation

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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