Potassium Metabolism in Chronic Kidney Disease

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

Adaptive increases in renal and gastrointestinal excretion of K+ help to prevent hyperkalemia in patients with CKD as long as the GFR remains greater than 15-20mL/min. In these patients K+ balance is maintained by increased K+ secretion per functioning nephron, which is mediated in part by elevated plasma K+ concentration, aldosterone, increased flow rate, and enhanced Na+-K+-ATPase activity. Fecal losses of potassium also increase in CKD. These adaptive mechanisms are effective in preventing hyperkalemia provided that urine output is in excess of 600mL/day. However, limits of adaptation render the CKD patient susceptible to hyperkalemia with even minor perturbations in these factors. Such is the case in patients with diabetes, where decreased mineralocorticoid activity is often an early finding, caused by hyporeninemic hypoaldosteronism, or in patients with renal injury primarily directed toward the tubule, as in tubulointerstitial renal disease. In these settings, hyperkalemia often develops with only mild or moderate reductions in GFR. Once the GFR falls to less than 15mL/min an inflection point is reached whereby small incremental losses in renal function require progressively steeper rises in steady state serum K+ concentration in order to maintain total body K+ balance. At this level of renal function the impact of factors known to adversely affect K+ homeostasis is significantly magnified. In clinical practice hyperkalemia is usually the result of a combination of factors superimposed on renal dysfunction.

Original languageEnglish (US)
Title of host publicationChronic Renal Disease
PublisherElsevier Inc.
Pages381-390
Number of pages10
ISBN (Electronic)9780124116160
ISBN (Print)9780124116023
DOIs
StatePublished - Jan 1 2015

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Keywords

  • Aldosterone
  • Chronic kidney disease
  • Collecting duct
  • Hyperkalemia
  • Mineralocorticoid
  • Potassium

ASJC Scopus subject areas

  • Medicine(all)

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