Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis

Yibing Yao, Yu Fan, Jun Wu, Haisu Wan, Jing Wang, Stephen Lam, Wan L. Lam, Luc Girard, Adi F. Gazdar, Zhihao Wu, Qinghua Zhou

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies than any single marker alone. Leave-one-out validation also showed significant relevance with all stages of NSCLC patients. The panel of autoantibodies has a high potential for detecting early stage NSCLC.

Original languageEnglish (US)
Pages (from-to)613-619
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume423
Issue number3
DOIs
StatePublished - Jul 6 2012

Keywords

  • Early diagnosis
  • NSCLC
  • SEREX
  • Tumor-associated autoantibodies

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis'. Together they form a unique fingerprint.

Cite this