Abstract
To identify a panel of tumor associated autoantibodies which can potentially be used as biomarkers for the early diagnosis of non-small cell lung cancer (NSCLC). Thirty-five unique and in-frame expressed phage proteins were isolated. Based on the gene expression profiling, four proteins were selected for further study. Both receiver operating characteristic curve analysis and leave-one-out method revealed that combined measurements of four antibodies produced have better predictive accuracies than any single marker alone. Leave-one-out validation also showed significant relevance with all stages of NSCLC patients. The panel of autoantibodies has a high potential for detecting early stage NSCLC.
Original language | English (US) |
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Pages (from-to) | 613-619 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 423 |
Issue number | 3 |
DOIs | |
State | Published - Jul 6 2012 |
Keywords
- Early diagnosis
- NSCLC
- SEREX
- Tumor-associated autoantibodies
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology