Pre-operative core muscle index in combination with hypoalbuminemia is associated with poor prognosis in advanced ovarian cancer

Lesley B. Conrad, Haitham Awdeh, Stefany Acosta-Torres, Steven A. Conrad, April A. Bailey, David S. Miller, Jayanthi S. Lea

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Objectives: Age and frailty have been correlated with poor clinical outcomes in cancer. Core muscle index (CMI) and nutritional status are integral in assessing frailty. We explored the effect of pre-operative serum albumin and body composition on clinical outcomes in patients with epithelial ovarian cancer (EOC). Methods: We identified stage III-IV EOC patients undergoing primary cytoreductive surgery from 2007 to 2015. Data were abstracted from medical records. Body composition measurements were obtained from pre-operative imaging. Psoas muscle cross-sectional area was normalized to height2 to determine CMI. Sarcopenia was defined as CMI below the population mean. The influence of sarcopenia on short-term morbidity was evaluated. Relationships among body composition measurements and albumin were assessed with Spearman correlations. Patient characteristics and body composition measurements between patients with and without sarcopenia were compared with parametric and non-parametric statistical methods. Kaplan-Meier survival curves were compared using log-rank. Results: 102 women met inclusion criteria. Sarcopenia correlated with albumin (P=0.0002). Sarcopenia was not associated with short-term morbidity or time to recurrence. Sarcopenia was associated with nearly a fourfold increased risk of death when hypoalbuminemia was present (P=0.02). Conclusions: Pre-operative sarcopenia in combination with hypoalbuminemia was associated with significantly worse survival.

Original languageEnglish (US)
JournalJournal of Surgical Oncology
DOIs
StateAccepted/In press - Jan 1 2018

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Sarcopenia
Hypoalbuminemia
Ovarian Neoplasms
Muscles
Body Composition
Albumins
Psoas Muscles
Morbidity
Kaplan-Meier Estimate
Nutritional Status
Serum Albumin
Medical Records
Recurrence
Survival

Keywords

  • Core muscle
  • Hypoalbuminemia
  • Ovarian cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Pre-operative core muscle index in combination with hypoalbuminemia is associated with poor prognosis in advanced ovarian cancer. / Conrad, Lesley B.; Awdeh, Haitham; Acosta-Torres, Stefany; Conrad, Steven A.; Bailey, April A.; Miller, David S.; Lea, Jayanthi S.

In: Journal of Surgical Oncology, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Background and Objectives: Age and frailty have been correlated with poor clinical outcomes in cancer. Core muscle index (CMI) and nutritional status are integral in assessing frailty. We explored the effect of pre-operative serum albumin and body composition on clinical outcomes in patients with epithelial ovarian cancer (EOC). Methods: We identified stage III-IV EOC patients undergoing primary cytoreductive surgery from 2007 to 2015. Data were abstracted from medical records. Body composition measurements were obtained from pre-operative imaging. Psoas muscle cross-sectional area was normalized to height2 to determine CMI. Sarcopenia was defined as CMI below the population mean. The influence of sarcopenia on short-term morbidity was evaluated. Relationships among body composition measurements and albumin were assessed with Spearman correlations. Patient characteristics and body composition measurements between patients with and without sarcopenia were compared with parametric and non-parametric statistical methods. Kaplan-Meier survival curves were compared using log-rank. Results: 102 women met inclusion criteria. Sarcopenia correlated with albumin (P=0.0002). Sarcopenia was not associated with short-term morbidity or time to recurrence. Sarcopenia was associated with nearly a fourfold increased risk of death when hypoalbuminemia was present (P=0.02). Conclusions: Pre-operative sarcopenia in combination with hypoalbuminemia was associated with significantly worse survival.",
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AU - Conrad, Lesley B.

AU - Awdeh, Haitham

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AU - Conrad, Steven A.

AU - Bailey, April A.

AU - Miller, David S.

AU - Lea, Jayanthi S.

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