Pre-treatment neutrophil/lymphocyte ratio and platelet/lymphocyte ratio are prognostic of progression in early stage classical Hodgkin lymphoma

Jay P. Reddy, Mike Hernandez, Jillian R. Gunther, Bouthaina S. Dabaja, Geoffrey V. Martin, Wen Jiang, Mani Akhtari, Pamela K. Allen, Bradley J. Atkinson, Grace L. Smith, Chelsea C. Pinnix, Sarah A. Milgrom, Zeinab Abou Yehia, Eleanor M. Osborne, Yasuhiro Oki, Hun Lee, Fredrick Hagemeister, Michelle A. Fanale

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To determine whether pre-treatment neutrophil/lymphocyte (NLR) or platelet/lymphocyte ratios (PLR) are predictive for progression in early-stage classical Hodgkin lymphoma (cHL), we derived NLR and PLR values for 338 stage I/II cHL patients and appropriate cut-off point values to define progression. Two-year freedom from progression (FFP) for patients with NLR ≥6·4 was 82·2% vs. 95·7% with NLR <6·4 (P < 0·001). Similarly, 2-year FFP was 84·3% for patients with PLR ≥266·2 vs. 96·1% with PLR <266·2 (P = 0·003). On univariate analysis, both NLR and PLR were significantly associated with worse FFP (P = 0·001). On multivariate analysis, PLR remained a significant, independent prognostic factor (P < 0·001).

Original languageEnglish (US)
Pages (from-to)545-549
Number of pages5
JournalBritish Journal of Haematology
Volume180
Issue number4
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

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Hodgkin Disease
Neutrophils
Blood Platelets
Lymphocytes
Therapeutics
Multivariate Analysis

Keywords

  • Hodgkin lymphoma
  • lymphocyte
  • neutrophil
  • platelet
  • refractory
  • relapse

ASJC Scopus subject areas

  • Hematology

Cite this

Pre-treatment neutrophil/lymphocyte ratio and platelet/lymphocyte ratio are prognostic of progression in early stage classical Hodgkin lymphoma. / Reddy, Jay P.; Hernandez, Mike; Gunther, Jillian R.; Dabaja, Bouthaina S.; Martin, Geoffrey V.; Jiang, Wen; Akhtari, Mani; Allen, Pamela K.; Atkinson, Bradley J.; Smith, Grace L.; Pinnix, Chelsea C.; Milgrom, Sarah A.; Abou Yehia, Zeinab; Osborne, Eleanor M.; Oki, Yasuhiro; Lee, Hun; Hagemeister, Fredrick; Fanale, Michelle A.

In: British Journal of Haematology, Vol. 180, No. 4, 01.02.2018, p. 545-549.

Research output: Contribution to journalArticle

Reddy, JP, Hernandez, M, Gunther, JR, Dabaja, BS, Martin, GV, Jiang, W, Akhtari, M, Allen, PK, Atkinson, BJ, Smith, GL, Pinnix, CC, Milgrom, SA, Abou Yehia, Z, Osborne, EM, Oki, Y, Lee, H, Hagemeister, F & Fanale, MA 2018, 'Pre-treatment neutrophil/lymphocyte ratio and platelet/lymphocyte ratio are prognostic of progression in early stage classical Hodgkin lymphoma', British Journal of Haematology, vol. 180, no. 4, pp. 545-549. https://doi.org/10.1111/bjh.15054
Reddy, Jay P. ; Hernandez, Mike ; Gunther, Jillian R. ; Dabaja, Bouthaina S. ; Martin, Geoffrey V. ; Jiang, Wen ; Akhtari, Mani ; Allen, Pamela K. ; Atkinson, Bradley J. ; Smith, Grace L. ; Pinnix, Chelsea C. ; Milgrom, Sarah A. ; Abou Yehia, Zeinab ; Osborne, Eleanor M. ; Oki, Yasuhiro ; Lee, Hun ; Hagemeister, Fredrick ; Fanale, Michelle A. / Pre-treatment neutrophil/lymphocyte ratio and platelet/lymphocyte ratio are prognostic of progression in early stage classical Hodgkin lymphoma. In: British Journal of Haematology. 2018 ; Vol. 180, No. 4. pp. 545-549.
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