Preclinical evaluation of 99mTc labeled gefitinib as a potential scintigraphic probe for the detection of tumors expressing epidermal growth factor receptors

Pardeep Kumar, Baljinder Singh, Anchal Ghai, Krishna Chuttani, Devinder Dhawan, Bhagwant R. Mittal, Anil K. Mishra

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In the present study, we successfully radiolabeled gefitinib with 99mTc by direct labeling method. The radio-ligand had radiolabeling efficiency of >95.0% and in vitro stability of >80.0% at 24h. The radiotracer cleared from blood bi-exponentially. Animal organ biodistribution data indicated hepato-renal excretion of the radiotracer. Scintigraphy carried out in tumor bearing mice (induced by EGFR expressing EAT cell lines) demonstrated that the radiotracer accumulated in the tumor site with T/NT ratio of 3.3±0.2 at 1h.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalApplied Radiation and Isotopes
Volume99
DOIs
StatePublished - May 1 2015
Externally publishedYes

Keywords

  • Tc
  • Epidermal growth factor receptor
  • Gefitinib
  • Molecular imaging

ASJC Scopus subject areas

  • Radiation

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