Precursor cell division during the immune response in vitro

Antigen induced and 'spontaneous' antibody forming cells

J. Kettman, E. Yin, R. W. Dutton

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

'Background' or 'spontaneous' plaque forming cells (PFC) which arise during in vitro culture of mouse spleen cells may be eliminated by a hot thymidine pulse. This does not prevent the subsequent addition of sheep red blood cells (SRBC) or trinitrophenylated (TNP) SRBC eliciting a primary immune response. Using mouse spleen recently resently primed by carrier (SRBC), it was found that an early 'hot pulse' (for the first 24 hr of culture) can eliminate the anti SRBC response, but not the primary anti TNP response which is dependent on carrier specific, theta bearing, radioresistant spleen cells.

Original languageEnglish (US)
Pages (from-to)655-656
Number of pages2
JournalEuropean Journal of Immunology
Volume3
Issue number10
StatePublished - 1973

Fingerprint

Cell Division
Sheep
Spleen
Erythrocytes
Antigens
Antibodies
Thymidine
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Precursor cell division during the immune response in vitro : Antigen induced and 'spontaneous' antibody forming cells. / Kettman, J.; Yin, E.; Dutton, R. W.

In: European Journal of Immunology, Vol. 3, No. 10, 1973, p. 655-656.

Research output: Contribution to journalArticle

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