Predicting Intellectual Outcome among Children Treated with 35-40 Gy Craniospinal Irradiation for Medulloblastoma

Shawna L. Palmer, Amar Gajjar, Wilburn E. Reddick, John O. Glass, Larry E. Kun, Shengjie Wu, Xiaoping Xiong, Raymond K. Mulhern

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

Fifty children diagnosed with medulloblastoma completed 188 psychological evaluations using the Wechsler Intelligence Scales for Children (D. Wechsler, 1974, 1991) over a 7-year study period following 35-40 Gy postoperative craniospinal irradiation. Random coefficient models were used to predict the trend in the children's intellectual performance as a function of time since diagnosis, with both patient and treatment variables as parameters of this function. A quadratic model demonstrated a delay prior to decline in performance for older patients, whereas the younger patients showed an immediate loss of performance with a plateau at approximately 6 years postdiagnosis. A steeper decline was found for those with higher baseline performance. Clinicians may use the proposed predictive model to identify those patients who are at risk of significant intellectual decline.

Original languageEnglish (US)
Pages (from-to)548-555
Number of pages8
JournalNeuropsychology
Volume17
Issue number4
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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    Palmer, S. L., Gajjar, A., Reddick, W. E., Glass, J. O., Kun, L. E., Wu, S., Xiong, X., & Mulhern, R. K. (2003). Predicting Intellectual Outcome among Children Treated with 35-40 Gy Craniospinal Irradiation for Medulloblastoma. Neuropsychology, 17(4), 548-555. https://doi.org/10.1037/0894-4105.17.4.548