Prediction of response to fluoxetine and placebo in children and adolescents with major depression: A hypothesis generating study

Robert A. Kowatch, Thomas J. Carmody, Graham J. Emslie, Jeannie W. Rintelmann, Carrol W. Hughes, A. John Rush

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Background: The results of multivariate analyses to identify potential predictors of response to fluoxetine or placebo separately in 96 child and adolescent outpatients with major depressive disorder from a recent controlled trial are presented. Methods: A variety of clinical, demographic and laboratory factors were examined as possible predictors of response to fluoxetine or placebo using logistic regression models. Results: No single variable or combination of variables strongly predicted response to fluoxetine. For the placebo group, a younger age, a shorter duration of depressive episode, and a lower socioeconomic status predicted response with an overall predictive power of 81%. Conclusions: This study is limited by the small sample size and should be considered hypothesis generating rather than confirming. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalJournal of affective disorders
Volume54
Issue number3
DOIs
StatePublished - Aug 1 1999

Keywords

  • Adolescents
  • Children
  • Fluoxetine
  • Major depressive Disorder
  • Placebo
  • Prediction of response

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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