Predictors of patients who will develop prolonged occult hypoperfusion following blunt trauma

Andrew M. Schulman, Jeffrey A. Claridge, Gordon Carr, Diana L. Diesen, Jeffrey S. Young

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Prolonged occult hypoperfusion or POH (serum lactate >2.4 mmol/L persisting >12 hours from admission) represents a reversible risk factor for adverse outcomes following traumatic injury. We hypothesized that patients at increased risk for POH could be identified at the time of admission. Methods: Prospective data from adult trauma admissions between January 1, 1998 and December 31, 2000 were analyzed. Potential risk factors for POH were determined by univariate analysis (p ≤ 0.10 = significant). Significant factors were tested in a logistic regression model (LR) (p ≤ 0.05 = significant). The predictive ability of the LR was tested by receiver operating curve (ROC) analysis (p ≤ 0.05 = significant). Results: Three hundred seventy-eight patients were analyzed, 129 with POH. Injury Severity Score (ISS), emergency department Glasgow Coma Scale score, hypotension, and the individual Abbreviated Injury Scale score (AIS) for Head (H), Abdominal/Pelvic Viscera (A) and Pelvis/Bony Extremity (P) were significantly associated with POH. LR demonstrated that ISS, A-AIS ≥3 and P-AIS ≥3 were independent predictors of POH (p < 0.05). ROC analysis of the LR equation was statistically significant (Area = 0.69, p < 0.001). Conclusions: We identified factors at admission that placed patients at higher risk for developing POH. Select patients may benefit from rapid, aggressive monitoring and resuscitation, possibly preventing POH and its associated morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)795-800
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume57
Issue number4
DOIs
StatePublished - Oct 2004

Fingerprint

Logistic Models
Abbreviated Injury Scale
Wounds and Injuries
Injury Severity Score
Glasgow Coma Scale
Viscera
Patient Admission
Pelvis
Resuscitation
Hypotension
Hospital Emergency Service
Lactic Acid
Extremities
Head
Morbidity
Mortality
Serum

Keywords

  • Head injury
  • Lactate
  • Muyltiple trauma
  • Pelvic fracture
  • Resuscitation
  • Shock

ASJC Scopus subject areas

  • Surgery

Cite this

Predictors of patients who will develop prolonged occult hypoperfusion following blunt trauma. / Schulman, Andrew M.; Claridge, Jeffrey A.; Carr, Gordon; Diesen, Diana L.; Young, Jeffrey S.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 57, No. 4, 10.2004, p. 795-800.

Research output: Contribution to journalArticle

Schulman, Andrew M. ; Claridge, Jeffrey A. ; Carr, Gordon ; Diesen, Diana L. ; Young, Jeffrey S. / Predictors of patients who will develop prolonged occult hypoperfusion following blunt trauma. In: Journal of Trauma - Injury, Infection and Critical Care. 2004 ; Vol. 57, No. 4. pp. 795-800.
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