Preliminary report: Treatment of type 3 hyperlipoproteinemia with mevinolin

Cara A. East, Scott M Grundy, David W. Bilheimer

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Type 3 hyperlipoproteinemia (HLP) results from the accumulation in plasma of remnants of very low density lipoproteins (VLDL) due to a defect in apolipoprotein E. Current data suggest that VLDL remnants can be removed by the same receptors that remove low density lipoproteins (LDL). Mevinolin has been shown to enhance clearance of LDL by LDL receptors. In this study, mevinolin markedly lowered both VLDL remnants and LDL in a patient with type 3 HLP, presumably by increasing the activity of LDL receptors.

Original languageEnglish (US)
Pages (from-to)97-98
Number of pages2
JournalMetabolism
Volume35
Issue number2
DOIs
StatePublished - Feb 1986

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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